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EC number: 236-152-1 | CAS number: 13194-48-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-08-27 to 1979-10-04
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethoprophos
- EC Number:
- 236-152-1
- EC Name:
- Ethoprophos
- Cas Number:
- 13194-48-4
- Molecular formula:
- C8H19O2PS2
- IUPAC Name:
- ethyl bis(propylsulfanyl)phosphinate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Microbiological Associates, Walkersville, Maryland
- Age at study initiation: not specified
- Weight at study initiation: 200 to 235 grams (males), 183 to 216 grams (females)
- Fasting period before study: overnight
- Housing: two animals/sex/dosage level in elevated wire-mesh cages
- Historical data: not specified
- Diet (ad libitum): commercial rodent ration (Purina Rodent Laboratory Chow®)
- Water (ad libitum): tap water
- Acclimation period: minimum of 3 weeks
- Method of randomisation in assigning animals to test and control groups: computerized randomization process (involved generating random numbers, assigning the numbers to the animals, ranking the random numbers, and assigning the animals to the groups)
ENVIRONMENTAL CONDITIONS
not specified
IN-LIFE DATES:
From: 1979-08-27 To: 1979-09-10 (females)
From: 1979-09-20 To: 1979-10-04 (males)
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Amount of vehicle: 10 mL/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 0, 10, 20, 40, 80 mg/kg bw
- No. of animals per sex per dose:
- 10 animals per sex and dose
- Control animals:
- yes
- Remarks:
- vehicle control group
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
All of the rats were observed for mortality and signs of toxic and pharmacologic effects at one, two, and four hours post-dose and twice daily thereafter for fourteen consecutive days. Individual body weights were recorded prior to treatment, at seven days, and at termination.
- Necropsy of survivors performed: yes, sacrifice by carbon dioxide asphyxiation
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 80 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 40 - < 80 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No males dosed at 0, 10, 20, or 40 mg/kg bw or females dosed at 10 or 20 mg/kg bw were found dead throughout the fourteen-day observation period. Three males dosed at 80 mg/kg bw were found dead on Day 2. One female dosed at 0 mg/kg, one dosed at 40 mg/kg bw, and all ten females dosed at 80 mg/kg bw were found dead on or before Day 2. The LD50 for the males was estimated to be greater than 80 mg/kg of body weight, and the LD50 for the females was estimated to be greater than 40 mg/kg of body weight but less than 80 mg/kg of body weight.
- Clinical signs:
- other: other: see "Remark"
- Body weight:
- other body weight observations
- Gross pathology:
- No observable gross pathology was noted in most rats which were not found dead during the observation period. Findings noted in two surviving 40 mg/kg bw females and one 10 mg/kg bw male included bright red lungs, dark red areas in the lungs, and dark red lungs. Findings noted in rats found dead during the fourteen-day period included dark red or bright red lungs, slightly reddened stomach lining, thin or thickened stomach walls, feed and gas in the stomach, dark or pale liver, and reddish-yellow material, air, brownish-yellow fluid, and/or yellowish fluid in the intestines.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- The acute oral LD50 of the test item in the rat was found to be >80 mg/kg bw (males) and 40-80 mg/kg bw (females) under the conditions of this study.
- Executive summary:
In a acute oral toxicity study similar to OECD 401, Fischer 344 rats (10/sex/group) were gavaged with the test item dissolved in corn oil at dose levels of 0, 10, 20, 40 or 80 mg/kg bw and observed for 14 days. Deaths occurred within 24 hours of administration at 40 (1F) and 80 mg/kg bw (3M, 10F); one control animal also died as a result of mis-dosing. Signs of toxicity (soft faeces, depression, rough coat, urine staining, red staining of the eyes and nose) were observed in all treated groups; findings had generally resolved by 24-48 hours following dosing but persisted to Day 7-9 in individual animals at 40 and 80 mg/kg bw. With the exception of two females at 40 mg/kg bw animals are reported to have gained weight over the study period, however actual values are not reported. Gross necropsy did not reveal any treatment-related findings in survivors. Dark/bright red lungs, slightly reddened stomach lining, thin or thickened stomach walls, dark or pale liver and discoloured gastrointestinal tract contents were noted in decedents.
The acute oral LD50 of the test item in the rat was found to be >80 mg/kg bw (males) and 40-80 mg/kg bw (females) under the conditions of this study.
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