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EC number: 217-199-7 | CAS number: 1772-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2022.07.29-2022.09.02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 022
- Report date:
- 2022
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Hexane-1,3,6-tricarbonitrile
- EC Number:
- 217-199-7
- EC Name:
- Hexane-1,3,6-tricarbonitrile
- Cas Number:
- 1772-25-4
- Molecular formula:
- C9H11N3
- IUPAC Name:
- hexane-1,3,6-tricarbonitrile
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- SPF
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:SAMTAKO BIO KOREA
- Age at study initiation:11 weeks
- Weight at study initiation:2307.9-2412.7
- Housing:Non-rodents 1
- Diet (e.g. ad libitum):libitum
- Water (e.g. ad libitum):libitum
- Acclimation period:3days at quarantine room and 5days at animal room.
ENVIRONMENTAL CONDITIONS
- Temperature (°C):18.5 ~ 19.7 ºC
- Humidity (%):51.5 ~ 62.8 %
- Air changes (per hr):10 ~ 15 air exchanges / hour
- Photoperiod (hrs dark / hrs light):12 hours light / 12 hours dark
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 1 in initial test
2 in confirmatory test
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all animals
- Time point:
- other: 1-21 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal: all animals
- Time point:
- other: 1-21 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: all animals
- Time point:
- other: 1-21days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No clinical signs and dead animals related to the test substance were observed.
As a result of observing eye reactions after administration of the test substance, the ocular mucosal reaction was not observed in the initial test and confirmatory test. As a result of calculating the eye response score, all eye response scores were calculated as 0.0 in the initial test and confirmatory test, and all eye response scores were calculated as 0.0 in the left site where no test substance was administered.
As a result, 1,3,6-Hexanetricarbonitrile was classified as non-irritating according to GHS "No category" due to no eye irritation / corrosion. - Executive summary:
This study was conducted to evaluate acute eye irritation / corrosion of 1,3,6-Hexanetricarbonitrile in female New Zealand White Rabbits, and the average score was calculated to distinguish the degree of response. In order to determine the eye irritation / corrosion potential, it was administered to the ocular mucosa to evaluate acute eye irritation / corrosion and severe eye damage when the test substance was exposed to the eye. There were no abnormal clinical signs or body weight changes observed. According to the guideline criteria for grading of eye reactions, no evidence of cornea and iris and conjunctivae was observed after 1 hour, so a confirmation test was conducted. In the confirmation test, the test substance (0.1 mL) was applied to two rabbits for 1 hours. The other eye, which remained untreated, was responsible for the control site. The animals were observed for 21 days.
The results of this study were as follows.
1) No death of animal was observed during the study period.
2) No clinical signs related to the test substance administration were observed.
3) No abnormal body weight changes were observed in initial and confirmatory tests. 4) As a result of observing eye reactions after administration of the test substance, the ocular mucosal reaction was not observed in the initial test and confirmatory test. As a result of calculating the eye response score, all eye response scores were calculated as 0.0 in the initial test and confirmatory test, and all eye response scores were calculated as 0.0 in the left site where no test substance was administered.
As a result, 1,3,6-Hexanetricarbonitrile was classified as non-irritating according to GHS "No category" due to no eye irritation / corrosion.
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