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EC number: 217-199-7 | CAS number: 1772-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2022.07.08-2022.09.28
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- SPF
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: SAMTAKO BIO KOREA
- Age at study initiation: 10 weeks
- Weight at study initiation: 2005.2-2041.6g
- Housing:Quarantine room 1
- Diet (e.g. ad libitum): libitum
- Water (e.g. ad libitum):libitum
- Acclimation period:3days in quarantine room, 5days in animal room
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18.4 ~ 20.3 ºC
- Humidity (%): 53.7 ~ 67.9 %
- Air changes (per hr): 10 ~ 15 air exchanges / hour
- Photoperiod (hrs dark / hrs light):12 hours light / 12 hours dark
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Remarks:
- 24 hours before administration of the test substance, the hair on the back of the rabbit was shaved to an area of about 15 cm x 15 cm using an electric hair remover to make healthy skin that has not been damaged.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- site A: 3 min
site B: 1 hour
site C: 4 hour - Observation period:
- 14 days
- Number of animals:
- 1 in initial test
2 in confirmatory test - Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: 6 cm²
- Type of wrap if used: a gauze patch, which was held in place with non-irritating tape. The entire trunk of the animals were wrapped with non-toxic adhesive tape (Tegaderm, 3M, U.S.A.) and carefully rinsed with sterilized distilled water to remove the residual test substance - Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 4-14 days
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 4-14 days
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No clinical signs and dead animals related to the test substance were observed.
No abnormal body weight changes were observed in initial or confirmatory tests.
As a result of observing skin reactions after administration of the test substance, no erythema/eschar formation and oedema were observed in both the initial test and the confirmatory test. The skin reaction score was calculated as 0.0 in both the initial test and the confirmatory test. The skin reaction score was calculated as 0.0 in control sites.
As a result, 1,3,6-Hexanetricarbonitrile was classified as “non-irritating” according to GHS "No category" due to no skin corrosion and irritation. - Executive summary:
This study was conducted to observe acute dermal irritation/corrosion of 1,3,6-Hexanetricarbonitrile in female New Zealand White rabbit and to determine the degree of irritation by calculating the skin reaction score. In order to determine the irritation/corrosion potential, three patches of test substance (0.5 mL) were sequentially applied for 3 mins, 1 hour and 4 hours, to approximately 6 cm2 of shaved skin on the dorsal area of one rabbit (occlusive exposure) during the initial test. After exposure, the test site was wiped with sterilized distilled water. According to the guideline criteria for grading of skin reactions, no evidence of erythema/eschar formation and oedema were observed after 4 hours, and therefore the confirmatory test was conducted. In the confirmatory test, the test substance (0.5 mL) was applied to two rabbits for 4 hours. The patch with the test substance was applied to the left site, and nothing was applied to the right site, as a control site. All animals were monitored for clinical signs and skin reaction during the 14 days observation period after administration.
The results of this study were as follows.
1) No death of animal was observed during the study period.
2) No clinical signs related to the test substance administration were observed.
3) No abnormal body weight changes were observed in initial and confirmatory tests.
4) As a result of observing skin reactions after administration of the test substance, no erythema/eschar formation and oedema were observed in both the initial test and the confirmatory test. The skin reaction score was calculated as 0.0 in both the initial test and the confirmatory test. The skin reaction score was calculated as 0.0 in control sites. As a result, 1,3,6-Hexanetricarbonitrile was classified as “non-irritating” according to GHS "No category" due to no skin corrosion and irritation.- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because an acute toxicity study by the dermal route does not indicate skin irritation up to the relevant limit dose level (2 000 mg/kg body weight)
- Endpoint:
- skin irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Justification for type of information:
- This in vivo study was performed to fullfill the information requirement of China and Korea authorities, it is generated before EU REACH registration .
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2022.07.29-2022.09.02
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Remarks:
- SPF
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source:SAMTAKO BIO KOREA
- Age at study initiation:11 weeks
- Weight at study initiation:2307.9-2412.7
- Housing:Non-rodents 1
- Diet (e.g. ad libitum):libitum
- Water (e.g. ad libitum):libitum
- Acclimation period:3days at quarantine room and 5days at animal room.
ENVIRONMENTAL CONDITIONS
- Temperature (°C):18.5 ~ 19.7 ºC
- Humidity (%):51.5 ~ 62.8 %
- Air changes (per hr):10 ~ 15 air exchanges / hour
- Photoperiod (hrs dark / hrs light):12 hours light / 12 hours dark - Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- 72 hours
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 1 in initial test
2 in confirmatory test - Irritation parameter:
- cornea opacity score
- Basis:
- animal: all animals
- Time point:
- other: 1-21 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal: all animals
- Time point:
- other: 1-21 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: all animals
- Time point:
- other: 1-21days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no adverse effect observed
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No clinical signs and dead animals related to the test substance were observed.
As a result of observing eye reactions after administration of the test substance, the ocular mucosal reaction was not observed in the initial test and confirmatory test. As a result of calculating the eye response score, all eye response scores were calculated as 0.0 in the initial test and confirmatory test, and all eye response scores were calculated as 0.0 in the left site where no test substance was administered.
As a result, 1,3,6-Hexanetricarbonitrile was classified as non-irritating according to GHS "No category" due to no eye irritation / corrosion. - Executive summary:
This study was conducted to evaluate acute eye irritation / corrosion of 1,3,6-Hexanetricarbonitrile in female New Zealand White Rabbits, and the average score was calculated to distinguish the degree of response. In order to determine the eye irritation / corrosion potential, it was administered to the ocular mucosa to evaluate acute eye irritation / corrosion and severe eye damage when the test substance was exposed to the eye. There were no abnormal clinical signs or body weight changes observed. According to the guideline criteria for grading of eye reactions, no evidence of cornea and iris and conjunctivae was observed after 1 hour, so a confirmation test was conducted. In the confirmation test, the test substance (0.1 mL) was applied to two rabbits for 1 hours. The other eye, which remained untreated, was responsible for the control site. The animals were observed for 21 days.
The results of this study were as follows.
1) No death of animal was observed during the study period.
2) No clinical signs related to the test substance administration were observed.
3) No abnormal body weight changes were observed in initial and confirmatory tests. 4) As a result of observing eye reactions after administration of the test substance, the ocular mucosal reaction was not observed in the initial test and confirmatory test. As a result of calculating the eye response score, all eye response scores were calculated as 0.0 in the initial test and confirmatory test, and all eye response scores were calculated as 0.0 in the left site where no test substance was administered.
As a result, 1,3,6-Hexanetricarbonitrile was classified as non-irritating according to GHS "No category" due to no eye irritation / corrosion.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
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