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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Remarks:
Read across data
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data from handbook or collection of data

Data source

Reference
Reference Type:
other:
Title:
Biphenyl (CICADS)
Author:
The International Programme on Chemical Safety (IPCS)-INCHEM
Year:
1999
Bibliographic source:
Biphenyl; Concise International Chemical Assessment Document 6; Joint FAO/WHO Expert Committee on Food Additives; 1999

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Guinea pig maximization test was conducted for test chemical to assess its skin sensitization potential in accordance with OECD Guideline 406
GLP compliance:
not specified
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,1'-biphenyl
Cas Number:
92-52-4
Molecular formula:
C12H10
IUPAC Name:
1,1'-biphenyl
Details on test material:
- Name of test material: Biphenyl
- Molecular formula: C12H10
- Molecular weight: 154.211 g/mol
- Smiles notation: c1(c2ccccc2)ccccc1
- InChl : 1S/C12H10/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material: Biphenyl
- Molecular formula: C12H10
- Molecular weight: 154.211 g/mol
- Smiles notation: c1(c2ccccc2)ccccc1
- InChl : 1S/C12H10/c1-3-7-11(8-4-1)12-9-5-2-6-10-12/h1-10H
- Substance type: Organic
- Physical state: liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
not specified

Study design: in vivo (non-LLNA)

Induction
Route:
other: No data available
Vehicle:
not specified
Concentration / amount:
No data available
Day(s)/duration:
No data available
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
other: No data available
Vehicle:
not specified
Concentration / amount:
No data available
Day(s)/duration:
No data available
Adequacy of challenge:
not specified
No. of animals per dose:
No data available
Details on study design:
No data available
Challenge controls:
not specified
Positive control substance(s):
not specified

Results and discussion

Positive control results:
not specified

In vivo (non-LLNA)

Results
Reading:
1st reading
Group:
test chemical
Dose level:
No data available
No. with + reactions:
0
Clinical observations:
There was no evidence of any skin sensitization reaction.
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: Not sensitizing
Conclusions:
The test material was considered to be not sensitizing to the guinea pigs’ skin.
Executive summary:

Guinea pig maximization test was conducted for chemical 1,1'-biphenyl (CAS no.: 92 -52 -4, E.C. no. 202 -163 -5) to assess its skin sensitization potential in accordance with OECD Guideline 406. Since the chemical did not induce any signs of contact sensitization, the test chemical was considered to be not sensitizing to the guinea pigs’ skin.