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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Remarks:
Read across data
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from secondary literature

Data source

Reference
Reference Type:
other: Secondary literature
Title:
in vivo skin irritation potential study of the test substance 2-Picoline.
Author:
U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS)
Year:
2009
Bibliographic source:
Hazard Characterization - Pyridine and Pyridine Derivatives Category, U. S. Environmental Protection Agency (EPA) Office of Pollution Prevention and Toxic Substances (OPPTS), 2009

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methylpyridine
EC Number:
203-643-7
EC Name:
2-methylpyridine
Cas Number:
109-06-8
Molecular formula:
C6H7N
IUPAC Name:
2-methylpyridine
Test material form:
liquid
Details on test material:
Substance name: 2-Picoline
CAS no.: 109-06-8
Mol. wt.: 93.13
Smiles: CC1=CC=CC=N1
Physicl state: Liquid
Purity: Not specified
Specific details on test material used for the study:
Substance name: 2-Picoline
CAS no.: 109-06-8
Mol. wt.: 93.13
Smiles: CC1=CC=CC=N1
Physicl state: Liquid
Purity: Not specified

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
not specified

Test system

Type of coverage:
not specified
Preparation of test site:
abraded
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
not specified
Duration of treatment / exposure:
not specified
Observation period:
not specified
Number of animals:
not specified
Details on study design:
not specified

Results and discussion

In vivo

Results
Irritation parameter:
edema score
Basis:
mean
Remarks on result:
positive indication of irritation

Applicant's summary and conclusion

Interpretation of results:
Category 2 (irritant) based on GHS criteria
Conclusions:
The test substance was found to be irritating to the rabbit skin.
Executive summary:

In vivo skin irritation study was performed in rabbits using test chemical 2 -Picoline (CAS no.: 109 -06 -8, E.C. no.: 203 -643 -7). Rabbits were treated with the test chemical. Test chemical was administered dermally to the animals onto the intact and abraded skin. Animals were further observed for clinical signs of irritation. Severe burning was accompanied by severe hyperemia and moderate edema after single application.Severe scar with moderate scabbing remained after 21 days. The test item was severely irritating to rabbit skin. Hence, the test chemical can be considered as "Category 2" according to the CLP.