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Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 26 SEP 2007 to 23 JAN 2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

25 200 mg/L

Temp.:

20 °C

pH:

4.5

Details on results:

The measured results differ by less than 15%. Therefore, the study is considered to be valid.

Table 2: Results of the Water Solubility of DIMETHYL 2-METHYL GLUTARATE

 

Sample N°.	Shaking time at 30°C	Concentration analyzed (mg/L)	Concentration calculated (g/L)	Water solubility calculated (rounded) (g/L)
1 2	72	49.989 50.887	24.99 25.44	25.20 SD = 0.19
3 4	48	50.172 50.480	25.09 25.24
5 6	24	50.764 50.065	25.38 25.03

 

The saturation mass concentration is calculated from the bold values.

SD = standard deviation

Conclusions:

The water solubility of DIMETHYL 2-METHYL GLUTARATE at 20 °C was determined to be 25.2 g/L (standard deviation ± 0.2 g/L) using the flask shaking method.

Executive summary:

The determination of the water solubility of DIMETHYL 2-METHYL was performed according to the EEC Directive 92/69, A.6 ”Water Solubility” (1992) and the OECD guideline No. 105, ”Water Solubility” (1995) using the flask shaking method.

 

The saturation concentration of DIMETHYL 2-METHYL GLUTARATE at room temperature was estimated by a simplified flask method in the preliminary test to be higher than 10^-2g/L. Therefore, the flask shaking test was used for the performance of the main test.

 

Vessels containing water and test item were shaken for 24 hours, 48 hours and 72 hours, respectively, at 30 °C. Afterwards the samples were equilibrated for another 24 hours at 20.0 °C. After dilution with acetonitrile the concentrations in the aqueous solutions were determined by a GC-method.

 

The water solubility of DIMETHYL 2-METHYL GLUTARATE at 20 °C was determined to be 25.2 g/L (standard deviation ± 0.2 g/L) using the flask shaking method.

Description of key information

 The water solubility of DIMETHYL 2-METHYL GLUTARATE at 20 °C was determined to be 25.2 g/L (standard deviation ± 0.2 g/L) using the flask shaking method.

Key value for chemical safety assessment

Water solubility:

25.2 g/L

at the temperature of:

20 °C

Additional information

One experimental study, scored as Klimisch 1, is available (Weissenfeld M., 2008) and selected as a key study.