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Diss Factsheets
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EC number: 701-365-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 10, 1982 - March 12, 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- according to guideline
- Guideline:
- other: Kanpogyo No. 5, Yakuhatsu No. 615, 49 Kikyoku No. 392: Bioaccumulation test of the chemical substances in fish and shellfish
- GLP compliance:
- not specified
- Radiolabelling:
- no
- Details on sampling:
- - Sampling intervals: Weeks 2, 3, 4, 6
- Details on sampling and analysis of test organisms and test media samples (e.g. sample preparation, analytical methods):
- For fish analysis
100 mL of 1 % Capriquart/benzene was added to 100 ppm methanol solution of the test substance. After drying, benzene was added to prepare the standard solution at the determined concentration.
- For water analysis
100 mL of 100 ppm Capriquart/benzene was added to 100 ppm methanol solution of the test substance. After drying, methanol was added to prepare the standard solution at the determined concentration. - Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Desalted water was added to 10 g of the test substance to make the total volume of 1 L, to give a final concentration of 10,000 ppm (w/v). No correction of the purity was conducted. Tis solution was diluted to the stock solution.
- Stock solution: water for dilution = 4 mL/minute : 400 mL/minute
stock solution for the first concentration area: 200 ppm (w/v) --> 2 ppm
stock solution for the second concentration area: 20 ppm (w/v) --> 0.2 ppm
- Controls: dilution water
- Evidence of undissolved material (e.g. precipitate, surface film, etc): no
Reasons for establishing the concentration:
The concentration at which quantitative analysis can be conducted with high accuracy is 7.5 ppb. The recovery rate was 95.4 % at 50-fold accumulation in the pretreatment procedures in the water analysis and from the result obtained by 5-day preliminary breeding reduction of the concentration in the aquarium was estimated to be 10 %. Therefore, the concentration in the aquarium of the second concentration area was established to be 0.2 ppm. The concentration in the first concentration area was determined to be 10-fold of those in the second concentration area. - Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- TEST ORGANISM
- Common name: Carp (Cyprinus carpio)
- Length at study initiation (mean): 10.6 cm
- Weight at study initiation (mean): 31.5 g
- Lipid content (mean): 4.7 %
- Description of housing/holding area: 100 L glass aquarium
- Flow rate: 582 L/day
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions: 25 °C
- External disinfection: 24-hour bathing in a 10 ppm chlortetracycline hydrochloride aqueous solution was conducted under the static water system. - Route of exposure:
- aqueous
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 6 wk
- Hardness:
- no data
- Test temperature:
- 24 °C to 26 °C
- pH:
- no data
- Dissolved oxygen:
- 2 ppm: 6.8 - 7.1 ppm
0.2 ppm: 6.5 - 6.8 ppm - TOC:
- no data
- Salinity:
- NA
- Details on test conditions:
- Test conditions
- Apparatus for controlling the aqueous system environment: Flow through system
Test aquarium: Glass-made
Volume 100 L
Flow rate 582 L/day - Nominal and measured concentrations:
- Nominal: 2.0 mg/L (ppm) -- Measured: 1.89 to 1.92 ppm
Nominal: 0.2 mg/L (ppm) -- Measured: 0.188 to 0.191 ppm - Reference substance (positive control):
- not specified
- Details on estimation of bioconcentration:
- BASIS INFORMATION
- Measured/calculated logPow: -4.3
- Results from toxicokinetic study: 30 % oral bioavailability in rats
- Results from residue study: -
- Monitoring data: -
BASIS FOR CALCULATION OF BCF
- Estimation software: EPIWEB 4.0
- Result based on measured log Pow of: -4.34
Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 1.51e-005 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.05 (BAF = 0.893 L/kg wet-wt)
- Result based on calculated log Pow of: -4.13
Log BCF (regression-based estimate): 0.50 (BCF = 3.16 L/kg wet-wt)
Biotransformation Half-Life (days) : 3.19e-006 (normalized to 10 g fish)
Log BAF (Arnot-Gobas upper trophic): -0.05 (BAF = 0.893 L/kg wet-wt) - Lipid content:
- 4.7 %
- Type:
- BCF
- Value:
- < 11
- Remarks on result:
- other: calculation based on detection limit
- Remarks:
- Conc.in environment / dose:0.2 mg/mL
- Type:
- BCF
- Value:
- < 1.1
- Remarks on result:
- other: calculation based on detection limit
- Remarks:
- Conc.in environment / dose:2 mg/L
- Details on kinetic parameters:
- no data
- Metabolites:
- no data
- Results with reference substance (positive control):
- no data
- Details on results:
- - Mortality of test organisms: no deaths
- Behavioural abnormalities: no
- Observations on body length and weight: NAD
- Other biological observations: none
- Results with vehicle control: NA - Reported statistics:
- NA
- Validity criteria fulfilled:
- yes
- Conclusions:
- The test substance does not bioaccumulate in aquatic test species
- Executive summary:
Freshwater fish Carp (Cyprinus carpio) were exposed to the test substance following a procedure as explained in METI. The sampling intervals were set at 2, 3, 4 and 6 week. No mortality or abnormal behavior were noticed during the study duration. At a concentration of 2 mg/L a BCF value of <1.1 was observed. Hence, it can be concluded that the test substance does not bioaccumulate in aquatic test species.
Reference
Description of key information
The test substance does not bioaccumulate in aquatic species.
Key value for chemical safety assessment
- BCF (aquatic species):
- 1.1 dimensionless
Additional information
Freshwater fish exposed to the test substance at concentration of 2 mg/L showed BCF value of <1.1. Hence, it can be concluded that the test substance does not bioaccumulate in aquatic test species.
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