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Administrative data

Key value for chemical safety assessment

Additional information

The test article was evaluated in an exploratory microbial mutation assay over a concentration range of 100 to 5000µg / plate Salmonella typhimuriumtest strains TA1535, TA97a, TA98, and TA100 and Escherichia colitest strain WP2 uvrA pKM101 were used, with and without metabolic activation (S-9 liver extract). The results indicated that the test article, up to the highest tested concentration, did not produce any 2 -fold or greater increases in revertants relative to the solvent control in any of the test strains, either with or without metabolic activation. Slight inhibition of revertant growth was noted in TA98 at 5000µg / plate with metabolic activation.

Short description of key information:

In an Ames study, the results indicated that the test article did not produce any 2-fold or greater increases in revertants in any of the test strains, either with or without metabolic activation.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The substance does not meet classification criteria under EU Directive 67/548/EEC for genetic toxicity.

The substance does not meet classification criteria under Regulation (EC) No 1272/2008 for genetic toxicity.