Registration Dossier
Registration Dossier
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EC number: 271-865-1 | CAS number: 68610-44-6
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Breath, urine, and blood measurements as biological exposure indices of short-term inhalation exposure to methanol.
- Author:
- Batterman, S.A. et al.
- Year:
- 1 998
- Bibliographic source:
- Int Arch Occup Environ Health 71: 325-335
Materials and methods
- Type of study / information:
- Determination of relationship between methanol concentration in the blood, urine, and breath of volunteers exposed to methanol vapors for 0.5 to 8 h.
- Endpoint addressed:
- basic toxicokinetics
- Principles of method if other than guideline:
- Determination of relationship between methanol concentration in the blood, urine, and breath of volunteers exposed to methanol vapors for 0.5 to 8 h.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Methanol
- EC Number:
- 200-659-6
- EC Name:
- Methanol
- Cas Number:
- 67-56-1
- Molecular formula:
- CH4O
- IUPAC Name:
- methanol
- Test material form:
- liquid
- Details on test material:
- Purity: > 94%
Constituent 1
Method
- Details on study design:
- Determination of relationship between methanol concentration in the blood, urine, and breath of volunteers exposed to 800 ppm (1.06 mg/l) methanol vapors for 0.5, 1, 2 and 8 h. The 0.5 to 2-h periods of exposure were used to estimate the half-life of methanol in blood, urine and breath.
- Exposure assessment:
- not specified
Results and discussion
- Results:
- For methanol, concentrations are not proportional to the exposure duration due to metabolic and other elimination processes that occur concurrently with the exposure. Blood data gave a half-life of 1.44 ± 0.33 h. Comparable but slightly more variable results were obtained using urine data corrected for the voiding time (1.55 ± 0.67 h) and breath data corrected for mucous membrane desorption (1.40 ± 0.38 h). Methanol concentrations in blood lagged some 15-30 min. behind the termination of exposure, and concentrations in urine were further delayed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
