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Diss Factsheets
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EC number: 217-468-9 | CAS number: 1863-63-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17. May 2017 - 01. June 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 608031
- Expiration date of the lot/batch: 25. Oct. 2018
- Purity test date: not stated
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature
- Stability under test conditions: assumed stable
- Solubility and stability of the test substance in the solvent/vehicle: soluble in alcohol and water and assumed stable
- Reactivity of the test substance with the solvent/vehicle of the cell culture medium: not expected
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
none
- Analytical method:
- high-performance liquid chromatography
- photometric method
- Key result
- Type:
- log Pow
- Partition coefficient:
- < 0.3
- Temp.:
- 25 °C
- pH:
- > 5 - < 6
- Type:
- log Pow
- Partition coefficient:
- ca. -0.399
- Temp.:
- 25 °C
- pH:
- > 5 - < 6
- Remarks on result:
- other: calculated result based on Equation of regression
- Conclusions:
- Due to the fact that the calculated log POW of the test item lay outside the calibrated range
(0.30 – 2.70) the log POW of Ammonium Benzoate is stated as < 0.3. - Executive summary:
The study was performed using a HPLC with a C18 column. Six reference items with different
retention times and thiourea for the determination of the dead time were used to
produce a calibration curve, since retention time on hydrophobic columns and POW are
correlated. The reference items were chosen based on the results of the pre-test.
One vial was filled with the reference item mix and one vial with the test item solution. The
vials were analysed using the HPLC with the program described in chapter 6.3.2. First one
injection from the solvent blank methanol/water 65/35 (v/v) was made. Then three injections
were measured from the reference item mix, three injections from the test item and
again three injections from the reference item mix.
For each reference item, the capacity factor k was calculated from the retention time of
thiourea and the retention time of the respective reference item.
A calibration function (log k versus log POW, linear fit) was determined using the literature
values for POW of the reference items and the retention times in the six determinations.
The chromatogram of the test item gave one peak. With the calibration function log k versus
log POW, the corresponding log POW value of the test item peak was determined with:
-0.399 ± 0.026
This value is the mean ± standard deviation of three independent determinations.
Due to the fact that the calculated log POW of the test item lay outside the calibrated range
(0.30 – 2.70) the log POW of Ammonium Benzoate is stated as < 0.3.
Reference
Description of key information
one Guideline study performed. For assessment, the calculated value based on the equation of regression is used.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -0.399
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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