Registration Dossier
Registration Dossier
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EC number: 947-982-5 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- RIFM Report, original study report not available
Data source
Referenceopen allclose all
- Reference Type:
- other: RIFM Database
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
- Reference Type:
- other: Monograph
- Title:
- 2,6-Dimethyl-2,4,6-Octatriene
- Year:
- 1 988
- Bibliographic source:
- Food and Chemical Toxicology 26 (4), 309
Materials and methods
- Principles of method if other than guideline:
- - Principle of test:
Pre-test for a human maximisation study
- Short description of test conditions: A 48 hour closed patch test was conducted on the backs of 22 healthy, male and female volunteers. - GLP compliance:
- no
Test material
- Reference substance name:
- (E,E)-2,6-dimethylocta-2,4,6-triene
- EC Number:
- 221-153-1
- EC Name:
- (E,E)-2,6-dimethylocta-2,4,6-triene
- Cas Number:
- 3016-19-1
- Molecular formula:
- C10H16
- IUPAC Name:
- (E,E)-2,6-dimethylocta-2,4,6-triene
- Test material form:
- liquid
1
- Specific details on test material used for the study:
- The test material (E,E)-2,6-dimethylocta-2,4,6-triene (EC 221-153-1) is the constituent of the registered substance.
Test animals
- Species:
- other: human
- Details on test animals or test system and environmental conditions:
- 22 healthy, male and female volunteers
Test system
- Type of coverage:
- other: closed patch on the back of volunteers
- Preparation of test site:
- not specified
- Vehicle:
- other: Petrolatum
- Controls:
- not specified
- Amount / concentration applied:
- 1% of test item in petrolatum
- Duration of treatment / exposure:
- Exposure 48 h
- Observation period:
- Not specified. Most probably immediately after exposure.
- Number of animals:
- 22
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Irritation
- Basis:
- other: All volunteers
- Remarks:
- Dose 1%
- Time point:
- 48 h
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Conclusions:
- No skin irritation observed in 22 male and female human volunteers exposed to 1% of 2,6 -dimethyl-2,4,6-octatriene (CAS 3016-19-1) in petrolatum for 48 hours
- Executive summary:
No skin irritation observed in 22 male and female human volunteers exposed to 1% of 2,6 -dimethyl-2,4,6-octatriene (CAS 3016-19-1) in petrolatum for 48 hours.
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