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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1982
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982
Reference Type:
other: Monograph
Title:
2,6-Dimethyl-2,4,6-Octatriene
Year:
1988
Bibliographic source:
Food and Chemical Toxicology 26 (4), 309

Materials and methods

Principles of method if other than guideline:
- Principle of test: Acute dermal toxicity in rabbits
- Short description of test conditions: 2 rabbits at high dose and 4 rabbits at other doses
- Parameters analysed / observed: LD50, mortality, systemic effects, gross necropsy
GLP compliance:
no
Test type:
other:
Limit test:
no

Test material

1
Chemical structure
Reference substance name:
(E,E)-2,6-dimethylocta-2,4,6-triene
EC Number:
221-153-1
EC Name:
(E,E)-2,6-dimethylocta-2,4,6-triene
Cas Number:
3016-19-1
Molecular formula:
C10H16
IUPAC Name:
(E,E)-2,6-dimethylocta-2,4,6-triene
Test material form:
liquid
Specific details on test material used for the study:
The test material (E,E)-2,6-dimethylocta-2,4,6-triene (EC 221-153-1) is the constituent of the registered substance.

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Doses:
1250, 1770, 2140, 2500 and 5000 mg/kg bw
No. of animals per sex per dose:
2 rabbits exposed to 5000 mg/kg bw, 4 rabbits exposed to other doses
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD0
Effect level:
ca. 1 250 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
LD0
Effect level:
ca. 1 770 mg/kg bw
Based on:
test mat.
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 400 mg/kg bw
Based on:
test mat.
95% CL:
>= 2 100 - 2 600
Sex:
not specified
Dose descriptor:
LD100
Effect level:
>= 2 500 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
LD100
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Sex:
not specified
Effect level:
ca. 2 140 mg/kg bw
Based on:
test mat.
Remarks on result:
other: 1/4 animals died
Mortality:
1250 mg/kg bw: no mortality
1770 mg/kg bw: no mortality
2140 mg/kg bw: 1/4 died
2500 mg/kg bw: 4/4 died
5000 mg/kg bw: 2/2 died
Clinical signs:
other: Negative righting reflex, prostration, lethargy, ptosis and few feces.
Gross pathology:
Abnormalities in lungs, heart, liver and intestines.

Applicant's summary and conclusion

Conclusions:
The acute dermal LD50 of 2,6-dimethyl-2,4,6-octatriene (CAS 3016-19-1) in rabbits is 2400 mg/kg bw (95% C.I. 2100-2600 mg/kg bw). Clinical signs observed were negative righting reflex, prostration, lethargy, ptosis and few feces. Necropsy of dead animals revealed abnormalities in lungs, heart, liver and intestines.
Executive summary:

The acute dermal LD50 of 2,6-dimethyl-2,4,6-octatriene (CAS 3016-19-1) in rabbits is 2400 mg/kg bw (95% C.I. 2100-2600 mg/kg bw). Clinical signs observed were negative righting reflex, prostration, lethargy, ptosis and few feces. Necropsy of dead animals revealed abnormalities in lungs, heart, liver and intestines.