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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1973
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Not specified.
GLP compliance:
no
Remarks:
Test carried out prior to GLP
Test type:
fixed dose procedure
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,7-dimethyloctan-1-ol
EC Number:
203-374-5
EC Name:
3,7-dimethyloctan-1-ol
Cas Number:
106-21-8
Molecular formula:
C10H22O
IUPAC Name:
3,7-dimethyloctan-1-ol

Test animals

Species:
other: Not specified
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
14 days
No. of animals per sex per dose:
6
Control animals:
no
Details on study design:
6 animals dosed

Results and discussion

Preliminary study:
none
Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
< 5 000 mg/kg bw
Based on:
test mat.
Mortality:
After 14 days:
- 4 animals found dead at the dose level tested.
Moderate erythema, morbidity (lethargy, malaise), prostration, coma and death.
Clinical signs:
other: Not specified
Gross pathology:
Dried cracked skin noted, persisting for 14 days.
Other findings:
See attachment.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test substance tested has an acute dermal LD50 of < 5.0 g/kg.