(3S)-3,7-Dimethyl-1-octanol

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1973

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Not specified.

GLP compliance:

no

Remarks:

Test carried out prior to GLP

Test type:

fixed dose procedure

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloctan-1-ol

EC Number:

203-374-5

EC Name:

3,7-dimethyloctan-1-ol

Cas Number:

106-21-8

Molecular formula:

C10H22O

IUPAC Name:

3,7-dimethyloctan-1-ol

Test animals

Species:

other: Not specified

Strain:

not specified

Sex:

not specified

Administration / exposure

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

14 days

No. of animals per sex per dose:

6

Control animals:

no

Details on study design:

6 animals dosed

Results and discussion

Preliminary study:

none

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LD50

Effect level:

< 5 000 mg/kg bw

Based on:

test mat.

Mortality:

After 14 days:
- 4 animals found dead at the dose level tested.
Moderate erythema, morbidity (lethargy, malaise), prostration, coma and death.

Clinical signs:

other: Not specified

Gross pathology:

Dried cracked skin noted, persisting for 14 days.

Other findings:

See attachment.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance tested has an acute dermal LD50 of < 5.0 g/kg.