Divinylbenzene

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authorative database

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

The short term aquatic toxicity of test material 1,2-di(ethenyl)benzene was evaluted for aquatic invertebrate

GLP compliance:

not specified

Specific details on test material used for the study:

-IUPAC name: 1,2-di(ethenyl)benzene-Mol. formula: C10H10-Molecular Weight: 131.1969 g/mol- Substance type: Organic- Physical state: Pale, straw-colored liquid

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Daphnia magna

Test type:

static

Water media type:

freshwater

Total exposure duration:

48 h

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

1.9 mg/L

Nominal / measured:

not specified

Conc. based on:

test mat.

Basis for effect:

mobility

Validity criteria fulfilled:

not specified

Conclusions:

The effect concentration (EC50) of test material 1,2-di(ethenyl)benzene on Daphnia magna after 48 h was observed to be 1.9 mg/l

Executive summary:

Short term toxicity to aquatic invertebrate was evaluated for Daphnia magna for the test chemical 1,2-di(ethenyl)benzene for 48 h . The effect concentration (EC50) of test material 1,2-di(ethenyl)benzene on Daphnia magna after 48 h was observed to be 1.9 mg/l. On the basis of above effect concentration it was considered that the test chemical is toxic to aquatic invertebrate . Hence, it can be classified as aquatic chronic-2 as per CLP criteria

Description of key information

Short term toxicity to aquatic invertebrate:

Short term toxicity to aquatic invertebrate was evaluated for Daphnia magna for the test chemical 1,2-di(ethenyl)benzene for 48 h . The effect concentration (EC50) of test material 1,2-di(ethenyl)benzene on Daphnia magna after 48 h was observed to be 1.9 mg/l. On the basis of above effect concentration it was considered that the test chemical is toxic to aquatic invertebrate . Hence, it can be classified as aquatic chronic-2 as per CLP criteria

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

1.9 mg/L

Additional information

Short term toxicity to aquatic invertebrate:

Data for target chemical 1,2-di(ethenyl)benzene along with its structurally similar read across substance was used to summarize the short term toxicity of test chemical:

1.Short term toxicity to aquatic invertebrate was evaluated for Daphnia magna for the test chemical 1,2-di(ethenyl)benzene for 48 h . The effect concentration (EC50) of test material 1,2-di(ethenyl)benzene on Daphnia magna after 48 h was observed to be 1.9 mg/l. On the basis of above effect concentration it was considered that the test chemical is toxic to aquatic invertebrate . Hence, it can be classified as aquatic chronic-2 as per CLP criteria.

2.Short term toxicity of test material was evaluated for aqutaic invertebrate Daphnia magna according to OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test). The effect concentration (EC50) of test chemical on Daphnia magna was evaluted to be 2.6 mg/l aftter 48 h of test exposure.

On the basis of above effect concentration it can be concluded that the test material is toxic to aquatic invertebrate . Hence, the test material an be classified as aquatic chronic - 2

3.Short term toxicity to aquatic invertebrate was evaluated for the test material , Daphnia magna Straus neonates, less than 20 hours old was used for the test . A 100 mg/ml stock solution of the test material in reagent grade DMF was prepared by weight to a precision of 0.1 mg; additional stocks were prepared by serial dilution.The test concentration selected were 0.56, 1 .00, 1.80, 3.20, and 5.60 mg/l.

The concentration of test material lethal to 50% of the test population and 95% confidence limits were determined for the 24 and 48 hour exposure periods by the Spearman-Karber Estimator.

The 48-hour LC50 and 95% confidence limits in Daphnia magna were 3.34 (2.69-4.13) mg/L. The 48-hour NOEC was observed to be 0.56 mg/L.

On the basis of above effect concentration it can be concluded that the test material is toxic to aquatic invertebrate . Hence, the test material an be classified as aquatic chronic - 2