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Diss Factsheets
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EC number: 236-195-6 | CAS number: 13223-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented report of a guideline study conducted to GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Details on test material:
- - Name of test material (as cited in study report): MADQUAT MC 75
- Substance type: organic
- Physical state: liquid
- Analytical purity: 75%
- Impurities (identity and concentrations): Water (25%)
- Composition of test material, percentage of components: 100%
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: stable
- Storage condition of test material: at room temperature and away from the light
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations:
- Sampling method: at 0 and 48 hours
- Sample storage conditions before analysis: no data
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Ultrapure water (ultrafiltration, activated carbon, ion exchange, 0.22 micron filter
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna Straus
- Strain: Clone 5 (Clone A)
- Source: In-house
- Age at study initiation: less than 24 hours
- Feeding during test: no
ACCLIMATION
- Acclimation period: no data
- Acclimation conditions (same as test or not): no data
- Type and amount of food: microscopic algae
- Feeding frequency: no data
- Health during acclimation (any mortality observed): no data
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- Not specified
- Test temperature:
- 19.5-20.5°C
- pH:
- 7.60 to 7.82
- Dissolved oxygen:
- 8.1 to 8.5 mg O2/l
- Nominal and measured concentrations:
- Nominal (mg/l): 0, 100, 135, 182.8, 246, 332.1, 448.4
Measured (initial) (mg/l): 0, 104.3, 145.1, 197.6, 267.4, 362.3, 488.2
Measured (final) (mg/l): 0, 91.8, 127.3, 174.0, 237.9, 322.5, 435.6 - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 ml beakers
- Aeration: non
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ultrapure
- Total organic carbon: not specified
- Particulate matter: not specified
- Metals: Ca and Mg = 2,5 mmol/l
- Pesticides: not specified
- Chlorine: not specified
- Alkalinity: not specified
- Ca/mg ratio: 4
- Conductivity: not specified
- Culture medium different from test medium: no
- Intervals of water quality measurement: not specified
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 24 hours darkness
- Light intensity: not applicable
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): immobilization
TEST CONCENTRATIONS
- Spacing factor for test concentrations: not specified
- Range finding study: yes
- Test concentrations: 0.1 to 100 mg/l
- Results used to determine the conditions for the definitive study: yes - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 104.3 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 488.2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 104.3 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 488.2 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid? Yes
- EC50/24 h: 0.83 mg/l
Any other information on results incl. tables
Concentration |
Immobilisation |
||||
Nominal |
Measured |
||||
Initial (mg/l) |
Final (mg/l) |
Final/initial | 24 hours (%) |
48 hours (%) |
|
448.4 | 488.2 | 435.6 | 89.2 | 20 | 25 |
332.1 | 362.3 | 322.5 | 89.0 | 15 | 20 |
246.0 | 267.4 | 237.9 | 88.9 | 10 | 10 |
182.8 | 197.6 | 174.0 | 88.0 | 5 | 10 |
135.0 | 145.1 | 127.3 | 87.7 | 5 | 5 |
100.0 | 104.3 | 91.8 | 88.0 | 0 | 0 |
0 | - | - | - | 0 | 5 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- MADQUAT MC 48 has a low toxicity to Daphnia magna under the test conditions. After 48 hours, the NOEC was 104.3 mg/l and the EC50 was over 488.2 mg/l.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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