Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vivo, other
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The EU RAR summarises the results of a number of studies of various designs and reilability.

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The EU RAR reports the results of a number of studies of various designs.
GLP compliance:
no
Type of assay:
other: Various methods

Test material

Constituent 1
Reference substance name:
Chromium
EC Number:
231-157-5
EC Name:
Chromium
Cas Number:
7440-47-3
Molecular formula:
Cr
IUPAC Name:
chromium

Test animals

Species:
other: rats and mice

Administration / exposure

Route of administration:
other: various
Duration of treatment / exposure:
Various treatment schedules were used
Frequency of treatment:
Various treatment schedules were used
Post exposure period:
Various protocols
No. of animals per sex per dose:
Various protocols were used

Examinations

Tissues and cell types examined:
Various: including bone marrow, liver, kidney, lung and germ cells

Results and discussion

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): positive
The EU RAR concludes, on the basis of the available information, that water-soluble Cr (VI) compounds are genotoxic in vivo in somatic cells and in germ cells.
Executive summary:

The EU RAR summarises the results of a number of studies of genotoxicity in vivo of various designs and different reliability. It is concluded, based on the weight of evidence, that water-soluble Cr (VI) compounds are genotoxic in vivo in somatic cells and in germ cells.