Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Title:
ACD/Percepta
Year:
2017
Bibliographic source:
(Advanced Chemistry Development, Inc., Pharma Algorithms, Inc., release 2017)

Materials and methods

Principles of method if other than guideline:
QSAR predition
GLP compliance:
no
Test type:
other: QSAR

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: granular
Specific details on test material used for the study:
C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
370 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD50 QSAR prediction was assessed as adequate for regulatory purposes.
Predicted value (model result): LD50 = 370 mg/kg