Registration Dossier

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Data source

Reference
Title:
ECOSAR (US EPA)
Year:
2017
Bibliographic source:
ECOSAR (US EPA) Version 2.0

Materials and methods

Principles of method if other than guideline:
- Software tool(s) used including version: ECOSAR Version 2.0 was released 2017
- Model(s) used: ECOlogical Structure-Activity Relationship Model (ECOSAR)
- Model description: see field 'Attached justification'
- Justification of QSAR prediction: see field 'Attached justification'
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: granular
Specific details on test material used for the study:
C1CCNC(C1)C(C2=CC=CC=C2)C(=O)O

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
6 125.75 mg/L
Remarks on result:
other: estimated water solubility 21022.54 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The prediction is adequate for the Classification and Labelling or risk assessment of the substance as indicated in REACH Regulation (EC) 1907/2006: Annex XI Section 1.3. The predictions do not indicate extreme or acute toxicities relevant for classification and labelling. The assessment indicates that the prediction is suitable for the regulatory conclusion in accordance with the tonnage driven information requirements.

Aliphatic Amines SAR: Green Algae 96-hr EC50 = 6125.75 mg/L*
*estimated water solubility 21022.54 mg/L