Registration Dossier
Registration Dossier
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EC number: 208-849-0 | CAS number: 543-80-6
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
Reliable substance-specific information concerning the toxicity for barium di(acetate) does not exist. Instead, toxicological information on soluble inorganic barium (mainly barium dichloride) substances and acetic acid and his salts were extrapolated to barium di(acetate) considering that systemic effects mainly based on the concentrations of the Ba2+ and acetate in solution. However, based on public available data on acetate, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded “Acetic acid, sodium diacetate, and calcium acetate are permitted food additives that may be added directly to food intended for human consumption without any limitation. This authorisation followed the assessment of safety by JECFA (1974, 1998) and the EU Scientific Committee on Food (SCF, 1990). JECFA considered acetic acid, calcium acetate, and sodium diacetate separately although data on acetic acid were primarily considered in each evaluation as no specific studies on sodium diacetate and calcium acetate were identified at that time. JECFA allocated an ADI of “not limited” (i.e., “not specified”) to acetic acid and its calcium salt in 1974 and this conclusion was retained when JECFA evaluated a group of saturated linear primary alcohols, aldehydes, and acids that included acetic acid in 1998.” (EFSA 2012)
Based on the above information, one can therefore safely assume that the acetate anion in barium di(acetate) does not contribute to the overall toxicity of barium di(acetate). It is concluded that only the effect of “barium” it further considered in the human health hazard assessment of barium di(acetate).
For read-across justification please refer to IUCLID section 7 "toxicological information" - "additional information" or to the report attached under IUCLID "0 category".
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 7
- Absorption rate - dermal (%):
- 1
- Absorption rate - inhalation (%):
- 7.5
Additional information
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