Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-406-9 | CAS number: 12220-06-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
- Principles of method if other than guideline:
- The 24-hour dermal toxicity was assessed using the technique of Noakes and Sanderson (1969).
Ref: Noakes DN. and Sanderson D.M. (1969) Br J Ind Med 26 59. - GLP compliance:
- no
- Remarks:
- pre GLP
- Limit test:
- yes
Test material
- Reference substance name:
- Acid Orange 067
- IUPAC Name:
- Acid Orange 067
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Alderley Park SPF.
- Weight at study initiation: 190 - 220 g
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST MATERIAL
Test item was applied as an aqueous paste.
REMOVAL OF TEST SUBSTANCE
After 24 hours the skin was washed with soap and water. - Duration of exposure:
- 24 hours
- Doses:
- 2500 mg/kg
- No. of animals per sex per dose:
- Three rats
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 other: mg/kg
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Clinical signs:
- other: The skins were stained orange by the material, but no toxic signs were noted during the experimental period.
- Gross pathology:
- At autopsy there were no gross or microscopic findings indicative of pathology.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified, according to the CLP Regulation (EC) No 1272/2008
- Conclusions:
- LD50 > 2500 mg/kg (females)
- Executive summary:
The 24-hour dermal toxicity was assessed using the technique of Noakes and Sanderson (1969). A group of three female rats (Alderley Park SPF albino strain) had 2500 mg/kg of the material, as an aqueous paste, applied for 24 hours under an occlusive dressing; the skin was then washed with soap and water and the animals observed for seven days.
The skins were stained orange by the material, but no toxic signs were noted during the experimental period. The 24-hour dermal LD50 is therefore greater than 2500 mg/kg. At autopsy there were no gross or microscopic findings indicative of pathology.
Conclusion
LD50 > 2500 mg/kg (females)
Ref: Noakes DN. and Sanderson D.M. (1969) Br J Ind Med 26 59.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
