Registration Dossier
Registration Dossier
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EC number: 259-627-5 | CAS number: 55406-53-6
Endpoint summary
Administrative data
Description of key information
Based on the experimental data available the test item is considered to be acutely toxic to both, marine and freshwater fish.
Available data on short-term and long-term toxicity to aquatic invertebrates imply toxic properties of the substance.
Additional information
Short-term toxicity to fish
Sheapshed minnow was exposed to the test item with nominal concentrations of 1.5, 0.90, 0.54, 0.32 and 0.19 mg/L under flow through conditions up to 96 h. Based on results obtained in this study, the test item is considered to be acutely toxic to fish.
Rainbow trout was exposed to test item nominal concenctrations of 150, 90, 54, 32 and 19 µg/L for 96 h under flow through conditions. Under the test conditions, the test item is considered to be acutely toxic to fish.
Bluegill sunfish was exposed to the test item with nominal concentrations of 500, 300, 180, 110 and 65 µg/L for 96 h under flow through conditions. Under the test conditions, the test item is considered to be acutely toxic to fish.
Short-term toxicity to aquatic invertebrates
In an 48 h acute toxicity study with daphnids under static conditions an LC50 value of 0.645 mg/L was determined.
Long-term toxicity to fish
In a GLP and guideline compliant study, early life stages of fathead minnow were exposed to test item concentrations of 57; 27; 19; 8.4; 4 µg/L (measured). Body length and wet weight were found to be the most sensitive indications of the test item toxicity. Respective NOEC was determined to be 8.4 µg/L.
Long-term toxicity to aquatic invertebrates
Chronic toxicity to water flea, daphnia magna, was studied under flow through conditions applying concentrations of 12.5, 25, 50, 100, 200 and 400 µg/L for 21 d. NOEC was determined to be 0.0499 mg/L
Toxicity to aquatic algae
The test item had a statistically significant inhibition effect on the growth (biomass and growth rate) of Scenedesmus subspicatus after the exposure period of 72 hours at concentrations of 10 µg/L (= 72-hour LOEC) and above. EC50 value for growth rate was determiend to be 53 µg/L.
Toxicity to microorganisms
In an OECD 209 equivalent study an EC50 of 44 mg/L was determined. The EC10 was determined to be 6.0 mg/L.
In a supporting study the inhibitory effect of the test item on the respiration rate of aerobic wastewater microorganisms of activated sludge was investigated in a 3-hour respiration inhibition test. NOEC was determined to be 45 mg/L.
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