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Diss Factsheets
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EC number: 204-588-1 | CAS number: 122-98-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09.01.2018 - 12.01.2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: A052-2017-HEA
- Expiration date of the lot/batch: 17 May 2019.
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored at ambient temperature without exposure to light in a tightly sealed container
- Stability under test conditions: stable
- Water solubility: 50 g/L ± 0.5 g/L at T = 20.0°C +/- 0.5 °C - Analytical monitoring:
- yes
- Details on sampling:
- Four samples from every freshly prepared test item concentration and the control (without algae) were
collected. One series of samples was transferred for chemical determinations at exposure initiation
and the other three series were stored under test conditions and next they were transferred for
chemical analyses daily.
Additionally, samples of pooled replicates (with algae) from every test item concentration plus the
control were collected and transferred for chemical analysis at exposure termination - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: Considering the test item’s density, 920 µL of the liquid test item were added into a flask with test
medium using a glass capillary pipette. The contents of the flask were filled up to a total volume of 2 L
with test medium. The resulting test item concentration of 500 mg/L was homogeneous and
transparent and used for exposure. The lower test item concentrations were prepared by sequential dilutions with the test medium. The control was test
medium (without test item). - Test organisms (species):
- Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)
- Details on test organisms:
- TEST ORGANISM
- Common name: Pseudokirchneriella subcapitata (Reinsch) Korshikov (syn. Raphidocelis subcapitata, Selenastrum capricornutum Prinz) SAG 61.81
- Source (laboratory, culture collection): Unicellular freshwater green algae Pseudokirchneriella subcapitata (Reinsch) Korshikov (syn. Selenastrum capricornutum Prinz, Raphidocelis
subcapitata Korshikov), specification SAG 61.81, cultured in the Institute of Industrial Organic Chemistry, Branch Pszczyna, Department of Ecotoxicology, Laboratory of Aquatic Toxicology, stock from the Culture Collection of Algae at Göttingen University, Germany. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
- Hardness:
- 20.3 mg/L as CaCO3
- Test temperature:
- 21.8 – 22.2ºC
- pH:
- 7.52 – 8.63
- Nominal and measured concentrations:
- Nominal: 500; 250; 125; 62.5; 31.3; 15.63; 7.81 and 3.91 mg/L plus the control
Measured: 485.0; 244.2; 104.1; 41.8; 17.7; 7.68; 4.43; 2.00; 0.00 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: The glass Erlenmeyer flasks with a capacity of 250 mL containing 100 mL of either the test item
concentration or the control plugged with air permeable stoppers were used as test vessels.
- Initial cells density: 1 x 104 cells per mL.
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 6
GROWTH MEDIUM
- Standard medium used: yes
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: The AAP medium (U.S. EPA) recommended by OECD Guideline No. 201 (2006) [1] was used as a culture medium for the test organism and a diluent/solvent of the test item.
OTHER TEST CONDITIONS
- Light intensity and quality: 5990 – 6800 lux; constant illumination
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- Determination of cell concentrations: was determined by counting the number of cells in the Bürker chamber under a microscope.
TEST CONCENTRATIONS
- Test concentrations: was determined on the basis of the preliminary (non-GLP) test results - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 254.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC10
- Effect conc.:
- 109.9 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Results with reference substance (positive control):
- - Results with reference substance valid? yes
- EC50: 3.23 mg/L - Validity criteria fulfilled:
- yes
Reference
Description of key information
With high propability, acutely not toxic to algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 254.6 mg/L
- EC10 or NOEC for freshwater algae:
- 109.9 mg/L
Additional information
Toxicity of 2 -Aminoethanol was tested in a study follwoing OECD 201 in a static system (study number 60E0452/14X656). The substance was tested in concentrations of 500; 250; 125; 62.5; 31.3; 15.63; 7.81 and 3.91 mg/L plus the controls. The sudy was accompanied by analytical verivication of the test concentrations. In controls with test substance but without addition of algae, the test item concentrations remained within +/-20% of nominal concentrations. However, the analytically verified concentrations in the test samples with alge varied more than 20% at the end of exposure compared to the initial concentration. Therefore, the final results of the study are experessed based on the arithemtic mean of the single test sample concentrations. The ErC50 turned out at 254 mg/L and the ErC10 was determined at 109.9 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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