p-anisylamine

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

data is from NTRL reports

Data source

Reference

Reference Type:

secondary source

Title:

Initial Submission: Acute Toxicity of 4-methoxybenzenemethanamine with Cover Letter dated 082692

Author:

NTRL report

Year:

1992

Bibliographic source:

OTS0546455, NTRL report, 1992

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

To determine the dermal irritation potential of 4-Methoxybenzylamine in guinea pigs

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

p-anisylamine

EC Number:

219-247-2

EC Name:

p-anisylamine

Cas Number:

2393-23-9

Molecular formula:

C8H11NO

IUPAC Name:

1-(4-methoxyphenyl)methanamine

Test material form:

liquid

Details on test material:

- Name of test material: 4-Methoxybenzylamine
- IUPAC name: p-anisylamine
- Molecular formula: C8H11NO
- Molecular weight: 137.181 g/mole
- Smiles :O(c1ccc(cc1)CN)C
- Inchl: 1S/C8H11NO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3
- Substance type: Organic
- Physical state: Liquid (Colorless to pale yellow)

Specific details on test material used for the study:

- Name of test material: 4-Methoxybenzylamine
- IUPAC name: p-anisylamine
- Molecular formula: C8H11NO
- Molecular weight: 137.181 g/mole
- Smiles :O(c1ccc(cc1)CN)C
- Inchl: 1S/C8H11NO/c1-10-8-4-2-7(6-9)3-5-8/h2-5H,6,9H2,1H3
- Substance type: Organic
- Physical state: Liquid (Colorless to pale yellow)

Test animals

Species:

guinea pig

Strain:

Hartley

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: range: 358 - 416 g

Test system

Type of coverage:

occlusive

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Controls:

not specified

Amount / concentration applied:

0.5 mL

Duration of treatment / exposure:

24 hours

Observation period:

14 days

Number of animals:

5

Details on study design:

Test substance was applied for 24 hour to the skin of guinea pigs under occlusive conditions. The effects on skin were observed for 14 days.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

14 d

Reversibility:

not specified

Remarks on result:

positive indication of irritation

Irritant / corrosive response data:

The test article was a strong skin irritant. It caused erythema, edema, necrosis, and subsequent eschar formation at the site of application. The eschars persisted throughout the 14-day observation period.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (corrosive) based on GHS criteria

Conclusions:

4-Methoxybenzylamine caused erythema, edema, necrosis, and subsequent eschar formation at the site of application. The eschars persisted throughout the 14-day observation period.
Since the effects were persistent throughout the observation period, 4-Methoxybenzylamine was considered to be corrosive to skin.

Executive summary:

The dermal irritation potential of 4-Methoxybenzylamine was assessed in guinea pigs.

4-Methoxybenzylamine was applied for 24 hour to the skin of 5 Hartley guinea pigs under occlusive conditions. The effects on skin were observed for 14 days.

4-Methoxybenzylamine caused erythema, edema, necrosis, and subsequent eschar formation at the site of application. The eschars persisted throughout the 14-day observation period.

Since the effects were persistent throughout the observation period, 4-Methoxybenzylamine was considered to be corrosive to skin.