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EC number: 219-247-2 | CAS number: 2393-23-9
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic/sediments:
Using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for 4-Methoxybenzylamine (CAS No. 2393-23-9) is 2.66 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical 4-Methoxybenzylamine is non bioaccumulative in food chain.
Additional information
Bioaccumulation: aquatic/sediments:
Predicted data studies for target chemical 4-Methoxybenzylamine (CAS No. 2393-23-9) have been conducted from different sources for bioaccumulation endpoint and their results are summarized below.
The first predicted data study was done by using BCFBAF Program (v3.00) model of EPI suite (2018) the estimated bio concentration factor (BCF) for 4-Methoxybenzylamine (CAS No. 2393-23-9) is 2.66 L/kg wet-wt at 25 deg. c which does not exceed the bioconcentration threshold of 2000. Therefore it is concluded that test chemical 4-Methoxybenzylamine is non bioaccumulative in food chain.
Next study was done by using Bio-concentration Factor (v12.1.0.50374) module in this study the Bio-concentration Factor of the chemical 4-Methoxybenzylamine (CAS no.2393 -23 -9) estimated to be 1.0 dimensionless at range pH 0-8 and in range from 1.14 to 3.41 dimensionless at range pH 9-14. These BCF values indicate that the chemical 4-Methoxybenzylamine is non-bioaccumulative in aquatic organisms as this value does not exceed 2000 criteria.
In another predicted data study the Bioconcentration factor (BCF) for test chemical 4-Methoxybenzylamine (CAS No: 2393-23-9) was predicted in aquatic organisms by using modeling database at pH 1-10 and temperature 25 °C . The Bioconcentration factor (BCF) of test substance 4-Methoxybenzylamine at pH 1-8 and temperature 25 °C was estimated to be 1.0 dimensionless. This BCF value at pH 1-8 and temperature 25 °C suggests that the test chemical 4-Methoxybenzylamine is non bioaccumulative in aquatic organisms.
Further The Bioconcentration factor (BCF) for test chemical 4-Methoxybenzylamine (CAS No: 2393 -23 -9) was predicted in aquatic organisms by Chemspider- ACD/PhysChem Suite at pH 5.5 and pH 7.4.The Bioconcentration factor (BCF) of test substance 4-Methoxybenzylamine at pH 5.5 and pH 7.4 was estimated to be 1.0 dimensionless. This BCF value suggests that the test chemical 4-Methoxybenzylamine is non bioaccumulative in aquatic organisms.
Last predicted data study was done from CompTox Chemistry Dashboard using OPERA (OPEn (quantitative) structure-activity Relationship Application) V1.02 model in which calculation based on PaDEL descriptors (calculate molecular descriptors and fingerprints of chemical) the bioaccumulation i.e BCF for test substance 4-Methoxybenzylamine (CAS no. 2393 -23 -9) was estimated to be 5.54 dimensionless .The predicted BCF result was based on the 5 OECD principles.
On the basis of all the studies mentioned above it can be concluded that Bioconcentration Factor of test chemical falls in range from 1.0 to 5.54 dimensionless. This range BCF value indicates that test chemical 4-Methoxybenzylamine (CAS no.2393 -23 -9) in non bioaccumulative in nature.
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