Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 215-180-8 | CAS number: 1310-53-8
Endpoint summary
Administrative data
Description of key information
Repeated dose toxicity inhalation:
The cross sectional study of 75 workers exposed to Ge and 79 matched referents aimed to assess occupational exposure to inorganic germanium (Ge) in workers from a producing plant, and to assess the health of these workers, with a special focus on respiratory, kidney, and liver functions (Swennen et al 2000). The observations from the epidemiological study showed no adverse effects on chronic exposure up to 300 μg Ge / m³ (metallic germanium and germanium dioxide and other inorganic germanium compounds). In particular, a relevance of local respiratory toxicity for this concentration range can be excluded. Indications of nephrotoxicity are also not sufficiently probable (no proteinuria based on tubular renal effects; only minimal changes in glomerular functional parameters). An exposure-related nephrotoxic effect could not be inferred from the observations.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
