(2S)-1,3,4,5,6,7-hexahydro-1,1,5,5-tetramethyl-2H-2,4a-methanonaphthalene

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

data is from peer-reviewed journal.

Data source

Reference

Reference 1

Reference Type:

publication

Title:

I. Acute Oral Toxicity

Author:

Jenner et al.

Year:

1964

Bibliographic source:

Food and Cosmetics Toxicology

Reference 2

Reference Type:

other: authoritative database

Title:

Acute oral toxicity by using test chemical

Author:

U.S. National Library of Medicine

Year:

2018

Bibliographic source:

ChemIDplus

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

Acute Oral toxicity test was carried out to study the effects of given test chemical on rats.

GLP compliance:

not specified

Test type:

other: not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one

EC Number:

225-160-0

EC Name:

(1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one

Cas Number:

4695-62-9

Molecular formula:

C10H16O

IUPAC Name:

(1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one

Test material form:

liquid

Details on test material:

- Name of test material (IUPAC name): (1S)-1,3,3-trimethylbicyclo[2.2.1]heptan-2-one
- Common name: (+)-Fenchone
- Molecular formula: C10H16O
- Molecular weight: 152.2354 g/mol
- Smiles notation: C[C@]12CC[C@H](C1)C(C)(C)C2=O
- InChl: 1S/C10H16O/c1-9(2)7-4-5-10(3,6-7)8(9)11/h7H,4-6H2,1-3H3/t7-,10+/m1/s1
- Substance type: Organic
- Physical State: Liquid

Test animals

Species:

rat

Strain:

Osborne-Mendel

Sex:

male/female

Details on test animals or test system and environmental conditions:

Details on test animal
TEST ANIMALS
- Age at study initiation: young and adult rats
- Fasting period before study: approximately 18 hr
- Diet (e.g. ad libitum):diet was provided ad libitum
- Water (e.g. ad libitum): water was provided ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Details on oral exposure:

not specified

Doses:

6160 mg/kg bw

No. of animals per sex per dose:

Groups of 10 males and 10 females

Control animals:

not specified

Details on study design:

Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: All animals were maintained under close observation for recording toxic signs and time of death.
- Other examinations performed: clinical signs

Statistics:

LD50'S were computed by the method of Litchfield & Wilcoxon (1949).

Results and discussion

Preliminary study:

not specified

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

6 160 mg/kg bw

Based on:

test mat.

95% CL:

4 400 - 8 630

Remarks on result:

other: 50% mortality was observed

Mortality:

Death time was observed from 4 hours to 9 days

Clinical signs:

Clinical signs like Depression, scrawny appearance, porphyrin-like deposit around eyes and nose for a week after treatment were observed.

Body weight:

not specified

Gross pathology:

not specified

Other findings:

not specified

Applicant's summary and conclusion

Interpretation of results:

other: not classified

Conclusions:

The lethal concentration (LD50) value for acute oral toxicity test was considered to be 6160 mg/kg bw (95% confidence limits: 4400-8630 mg/kg bw), when group of 10 male and female Osborne-Mendel rats were treated with the given test chemical orally via gavage.

Executive summary:

Acute oral toxicity study was performed in group of 10 male and female Osborne-Mendel rats using test chemical. Death time was observed from 4 hours to 9 days. Clinical signs like Depression, scrawny appearance, porphyrin-like deposit around eyes and nose for a week after treatment were observed. Hence, LD50 value was considered to be 6160 mg/kg bw (95% confidence limits:4400-8630 mg/kg bw), when groups of 10 male and female Osborne-Mendel rats were treated with the given test chemical orally via gavage.