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EC number: 214-494-2
CAS number: 1135-66-6
A maximization test (Kligman, 1966; Kligman
and Epstein, 1975) was carried out with 10% (6900 µg/cm2)
test material in petrolatum on 26 male volunteers. Test material was
applied under occlusion to the same site on the forearms of 26 male
subjects for five alternate day, 48-h periods. Patch sites were
pre-treated for 24 h with 5% aqueous sodium lauryl solution (SLS) under
occlusion for the initial patch only. After 10–14 day
rest period, a challenge patch was applied to a fresh site for 48 h
Challenge applications were preceded by 30
minute applications of 5% aqueous SLS under occlusion on the left side
whereas is test material was applied without SLS treatment on the right
side. No sensitization reactions were observed. Hence, test material
was considered to be not sensitizing to skin.
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