Registration Dossier
Registration Dossier
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EC number: 204-376-9 | CAS number: 120-20-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Fragrance raw materials monographs :p-METHOXYPHENYLACETONE
- Author:
- D. L. J. Opdyke
- Year:
- 1 979
- Bibliographic source:
- Food and Cosmetics Toxicology,Volume 17, Supplement, Pages 695-923 (December 1979)
- Reference Type:
- other: Authoritative database
- Title:
- Acute dermal toxicity study of 4-Methoxyphenylacetone (122-84-9) in rabbits
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- Chemidplus Database,U.S. National Library of Medicine,2017
- Reference Type:
- secondary source
- Title:
- Acute oral toxicity study of 4-Methoxyphenylacetone (122-84-9) in rat
- Author:
- RTECS
- Year:
- 2 017
- Bibliographic source:
- RTECS (registry of toxic effect of chemical substance database), 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity test was carried out to study the effects of 4-Methoxyphenylacetone (122-84-9) on rabbits.
- GLP compliance:
- no
- Test type:
- other: No data available
- Limit test:
- no
Test material
- Reference substance name:
- 4-methoxyphenylacetone
- EC Number:
- 204-578-7
- EC Name:
- 4-methoxyphenylacetone
- Cas Number:
- 122-84-9
- Molecular formula:
- C10H12O2
- IUPAC Name:
- 1-(4-methoxyphenyl)propan-2-one
- Details on test material:
- - Name of test material (IUPAC name): 1-(4-methoxyphenyl)propan-2-one
- Common name: 4-Methoxyphenylacetone
- Molecular formula: C10H12O2
- Molecular weight: 164.203 g/mol
- Smiles notation: c1(ccc(OC)cc1)CC(C)=O
- InChl: 1S/C10H12O2/c1-8(11)7-9-3-5-10(12-2)6-4-9/h3-6H,7H2,1-2H3
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report):p-Methoxyphenylacetone
- Molecular formula :C10H12O2
- Molecular weight :164.203 g/mol
- Substance type:Organic
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data available
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed in treated rabbits at 5000 mg/kg bw
- Mortality:
- No mortality was observed in treated rabbits at 5000 mg/kg bw.
- Clinical signs:
- No data available
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- The LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with 4-Methoxyphenylacetone (122-84-9) by dermal application.
- Executive summary:
In acute dermal toxicity study,rabbits were treated with 4-Methoxyphenylacetone (122-84-9) in the concentration of 5000 mg/kg bw by dermal application.No mortality was observed in treated rabbits at dose 5000 mg/kg bw.Therefore, LD50 value was considered to be >5000 mg/kg bw,when rabbits were treated with 4-Methoxyphenylacetone (122-84-9) by dermal application.
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