Registration Dossier
Registration Dossier
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EC number: 204-376-9 | CAS number: 120-20-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from authoritative database.
Data source
Reference
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity study of 1,2-dimethoxy-benzene (91-16-7) in rat.
- Author:
- U.S. National Library of Medicine
- Year:
- 2 017
- Bibliographic source:
- ChemIDplus, A TOXNET DATABASE, Lite Browse Advanced, 2017.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study of 1,2-dimethoxy-benzene (91-16-7) in rat.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Veratrole
- EC Number:
- 202-045-3
- EC Name:
- Veratrole
- Cas Number:
- 91-16-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,2-dimethoxybenzene
- Details on test material:
- Name: 1,2-dimethoxy-benzene
InChI: 1S/C8H10O2/c1-9-7-5-3-4-6-8(7)10-2/h3-6H,1-2H3
Smiles: c1(c(cccc1)OC)OC
- Name of test material:Veratrole
- Molecular formula:C8H10O2
- Molecular weight:138.165 g/mol
- Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- Name: 1,2-dimethoxy-benzene
InChI: 1S/C8H10O2/c1-9-7-5-3-4-6-8(7)10-2/h3-6H,1-2H3
Smiles: c1(c(cccc1)OC)OC
- Name of test material:Veratrole
- Molecular formula:C8H10O2
- Molecular weight:138.165 g/mol
- Substance type:Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 890 mg/kg
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 890 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 50% mortality was observed
- Mortality:
- 50% mortality was observed at 890 mg/kg bw.
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- LD50 was considered to be 890 mg/kg bw, when rat was treated with 1,2-dimethoxy-benzene (91-16-7) via oral route.
- Executive summary:
Acute oral toxicity study of 1,2-dimethoxy-benzene (91-16-7) was conducted in rat at the concentration of 890 mg/kg. 50% mortality was observed at 890 mg/kg bw. Therefore, LD50 was considered to be 890 mg/kg bw, when rat was treated with 1,2-dimethoxy-benzene via oral route.
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