Registration Dossier
Registration Dossier
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EC number: 247-063-2 | CAS number: 25513-64-8
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Abstract
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
- Principles of method if other than guideline:
- Preliminary LD50 for dose selection
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- 2,2,4(or 2,4,4)-trimethylhexamethylenediamine
- IUPAC Name:
- 2,2,4(or 2,4,4)-trimethylhexamethylenediamine
- Test material form:
- other: liquid
- Details on test material:
- 2,2,4(or 2,4,4)-trimethylhexamethylenediamine of Hüls AG, purity not reported.
Constituent 1
Test animals
- Species:
- hamster, Chinese
- Strain:
- other: Han-Chinese
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Age: 3 to 4 months
- Source: Zentralinstitut für Versuchskunde, Hanover (Germany)
- No. of animals per dose: 1 male + 1 female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- ADMINISTRATION:
- Vehicle: water (aqua ad injectabilia); 10 ml/kg bw applied
- Post dose observation period: not reported - Doses:
- 30; 60; 125; 250 mg/kg bw
- No. of animals per sex per dose:
- 1
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 125 mg/kg bw
- Mortality:
- MORTALITY:
250 mg/kg bw: 2/2 animals died within 3 hours.
125 mg/kg bw: The male died within 24 hours. - Clinical signs:
- CLINICAL SIGNS:
250 mg/kg bw: Severe apathia, sedation, hypothermia, loss of general reactions, reduced righting reflexes, temporarily Writhing reflexes as a
sign of abdominal pain reactions, irregular respiration (dyspnea).
125 mg/kg bw: Similar signs but less severe, recovery of surviving animal
60 mg/kg bw: Slight apathia (transient)
30 mg/kg bw: No signs
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
