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EC number: 209-669-5 | CAS number: 590-01-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The study was conducted as per the method outlined in the publication - Alsop, G.M.; Waggy, G.T.; Conway, R.A., Bacterial Growth Inhibition Test, Journal Water Pollution Control Federation, Volume 52, No. 10, October 1980 and the report contains sufficient information to permit a meaningful evaluation of study results
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Alsop, G.M.; Waggy, G.T.; Conway, R.A., Bacterial Growth Inhibition Test, Journal Water Pollution Control Federation, Volume 52, No. 10, October 1980
- Deviations:
- no
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- Butyl propionate
- EC Number:
- 209-669-5
- EC Name:
- Butyl propionate
- Cas Number:
- 590-01-2
- Molecular formula:
- C7H14O2
- IUPAC Name:
- butyl propanoate
- Details on test material:
- - Name of test material (as cited in study report): n-butyl propionate
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- not applicable
Test solutions
- Vehicle:
- not specified
- Details on test solutions:
- no data
Test organisms
- Test organisms (species):
- other: no data
- Details on inoculum:
- no data
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 16 h
- Post exposure observation period:
- not applicable
Test conditions
- Hardness:
- no data
- Test temperature:
- 22 ± 2 °C
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- not applicable
- Nominal and measured concentrations:
- no data
- Details on test conditions:
- The study was conducted as per the method outlined in the publication - Alsop, G.M.; Waggy, G.T.; Conway, R.A., Bacterial Growth Inhibition Test, Journal Water Pollution Control Federation, Volume 52, No. 10, October 1980. The test material n-butyl propionate was evaluated at selected conentrations in a mixture containing buffer, nutrients, growth substrate and microorganisms. The mixture of 1 ml of a suspension of seed microorganisms, 20 ml of dilution water, 4 ml of stock buffer solution, 10 ml of yeast extract/sodium acetate solution and 4 ml of aqueous solution of n-butyl propionate were incubated in an 8-ounce, narrow neck, round bottle for 16 hours on a platform shaker at ambient temperature (22 ± 2 °C). Seeded control bottles were used to measure growth or turbidity generated during the 16 hours without the test material. The bottles were stoppered with cotton plugs during shaking to avoid contamination.
The degree of inhibition was assessed from measuring (optical density at 530 nm) the turbidity levels of the test material at various concentrations. The measured optical density values were calculated as a percentage of the seeded growth control system. The percentage of control values were then plotted against the log of test sample concentration. The test concentration corresponding to 50 percent of the control was termed as 50 percent inhibition concentration (IC50). - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 16 h
- Dose descriptor:
- IC50
- Effect conc.:
- 508 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: turbidity measurements
- Details on results:
- no data
- Results with reference substance (positive control):
- not applicable
- Reported statistics and error estimates:
- no data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Under the conditions of the study, the IC50 of n-butyl propionate was 508 mg/l.
- Executive summary:
The study was conducted as per the method outlined in the publication - Alsop, G.M.; Waggy, G.T.; Conway, R.A., Bacterial Growth Inhibition Test, Journal Water Pollution Control Federation, Volume 52, No. 10, October 1980. The test material n-butyl propionate was evaluated at selected conentrations in a mixture containing buffer, nutrients, growth substrate and microorganisms. The mixture of 1 ml of a suspension of seed microorganisms, 20 ml of dilution water, 4 ml of stock buffer solution, 10 ml of yeast extract/sodium acetate solution and 4 ml of aqueous solution of n-butyl propionate were incubated in an 8-ounce, narrow neck, round bottle for 16 hours on a platform shaker at ambient temperature (22 ± 2 °C). Seeded control bottles were used to measure growth or turbidity generated during the 16 hours without the test material. The bottles were stoppered with cotton plugs during shaking to avoid contamination.
The degree of inhibition was assessed from measuring (optical density at 530 nm) the turbidity levels of the test material at various concentrations. The measured optical density values were calculated as a percentage of the seeded growth control system. The percentage of control values were then plotted against the log of test sample concentration. The test concentration corresponding to 50 percent of the control was termed as 50 percent inhibition concentration (IC50). Under the conditions of the study, the IC50 of n-butyl propionate was 508 mg/l.
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