Registration Dossier
Registration Dossier
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EC number: 208-289-7 | CAS number: 520-27-4
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Key study. Study on the analogue substance naringin, according to OECD TG 201 / EU Method C.3 (GLP study). The 72h-EC50 of the test item in freshwater algae was determined to be > 100 mg/L, the overall NOEC was determined to be 100 mg/L and the overall LOEC > 100 mg/L, all based on growth rate. Based on the available information for the read-across approach, the target substance has a 72h-EC50 > 104.8 mg/L and a NOEC ≥ 104.8 mg/L in algae.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 104.8 mg/L
- EC10 or NOEC for freshwater algae:
- 104.8 mg/L
Additional information
A freshwater algae growth inhibition Limit Test was performed on the analogue substance naringin, according to OECD 201 / EU Method C.3, under GLP conditions. Based on the results of a range finding study, six replicate cultures of Pseudokirchneriella subcapitata was exposed to 100 mg/L test item (nominal) or medium (negative control) for 72h under static conditions. All validity criteria were met. The 72h-EC50 of the test item in freshwater algae was determined to be > 100 mg/L (nominal, basis for effect: growth rate, yield and biomass). The overall NOEC was determined to be 100 mg/L (nominal) and the overall LOEC was determined to be > 100 mg/L (nominal). Based on the available information for the read-across approach, the target substance has a 72h-EC50 > 104.8 mg/L and a NOEC ≥ 104.8 mg/L in algae.
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