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Diss Factsheets
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EC number: 205-771-9 | CAS number: 150-78-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Published unavailable after INIST request
Data source
Reference
- Reference Type:
- publication
- Title:
- Fundamental studies of safe compound perfumes for cosmetics. Part 1. The primary irritation of compound materials to the skin
- Author:
- Takenaka T. , Hasegawa E. , Takenaka U. , Saito F. and Odaka T.
- Year:
- 1 986
- Bibliographic source:
- Unknown Source, pp. 313-329.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- not specified
Test material
- Reference substance name:
- 1,4-dimethoxybenzene
- EC Number:
- 205-771-9
- EC Name:
- 1,4-dimethoxybenzene
- Cas Number:
- 150-78-7
- Molecular formula:
- C8H10O2
- IUPAC Name:
- 1,4-dimethoxybenzene
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- not specified
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 4737 (30-200 patients each time)
- Sex: men/women
- Age: 16+ years
- Race: Japanese
- Demographic information: no data
- Other: The period of study extended over 4 yrs and 3 months and patch testing was performed 1-3 times per month; September to May (summer months were excluded). The total number of subjects was 4737 (2341 Japanese men and 2396 Japanese women aged 16-45, mostly 17-30, living in Tokyo and Osaka). Volume dose not provided - Clinical history:
- no data
- Controls:
- no data
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Patches consisted of a piece of 1 cm2 lint with a 2 cm2 cellophane disc placed on the lint and then covered with 4 cm2 plaster
- Vehicle / solvent: a base cream or 99% ethanol
- Concentrations: 0.05-0.5%
- Volume applied: no data
- Testing/scoring schedule: application for 24 or 48 h
- Removal of test substance: no data
- Other: /
EXAMINATIONS (important)
- Grading/Scoring system: The skin reaction was graded as follows: - No visible reaction; +- Slight erythema; + Erythema; ++ Erythema and swelling or marked erythema.
Results and discussion
- Results of examinations:
- Not sensitizing, no more information.
Applicant's summary and conclusion
- Conclusions:
- Patch test of the substance at concentration of 0.05 to 0.5% did not show any skin sensitization reaction in human.
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