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EC number: 221-043-3 | CAS number: 2983-37-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male Wistar rats were exposed to 1 percent of the test item in 40 percent alcohol for 2 h (whole body exposure).
- GLP compliance:
- no
- Remarks:
- study performed before implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl 2-ethylhexanoate
- EC Number:
- 221-043-3
- EC Name:
- Ethyl 2-ethylhexanoate
- Cas Number:
- 2983-37-1
- Molecular formula:
- C10H20O2
- IUPAC Name:
- ethyl 2-ethylhexanoate
- Details on test material:
- - Name of test material (as cited in study report): 2-ethyl-ethyl-capronat
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkeimann GmbH, Borchen, Germany
- Age at study initiation: young adult
- Weight at study initiation: 130 - 150 g
- Fasting period before study: no
- Housing: in type 3 makrolon cages
- Diet (e.g. ad libitum): Altromin maintainance diet, 1324, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: 5 d
ENVIRONMENTAL CONDITIONS
- Temperature (°C): approx. 22
- Humidity (%): approx. 50
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: 40% ethanol
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: inhalation exsiccator
- Exposure chamber volume: no data
- System of generating particulates/aerosols: nebuliser
TEST ATMOSPHERE
- Brief description of analytical method used: no data
VEHICLE
- Composition of vehicle (if applicable): 40% EtOH
- Concentration of test material in vehicle (if applicable): 1%
- Justification of choice of vehicle: relatively intoxic to rat
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: no data - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 2 h
- Concentrations:
- 1%
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, histopathology of upper trachea, mid trachea, lung (3 test animals + 3 control animals)
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 1 other: %
- Based on:
- other: test item in 40% EtOH
- Exp. duration:
- 2 h
- Remarks on result:
- other: corresponds to 100 mg/animal/2 h
- Sex:
- male
- Dose descriptor:
- LC0
- Effect level:
- 7.4 mg/L air (nominal)
- Based on:
- act. ingr.
- Exp. duration:
- 2 h
- Remarks on result:
- other: recalculated from exposure/animal
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 3.7 mg/L air (nominal)
- Based on:
- act. ingr.
- Exp. duration:
- 4 h
- Remarks on result:
- other: extrapolated from 2 h value
- Mortality:
- no animals died
- Clinical signs:
- other: no clinical signs apart from temporarily impaired general condition directly after inhalation exposure
- Body weight:
- no data
- Gross pathology:
- Pathologically and histologically no compound specific alterations of the target organs (respiratory tract) could be observed.
Any other information on results incl. tables
recalculation from 100 mg / animal to concentration in air:
- respiratory volume (rat) = 0.048 m³/ h / kg bw
- body weight of animal in study: 130 - 150 g (taken for calculation 140 g)
- > respiratory volume per animal in 2 h = 0.048 * 2 h * 0.14 kg = 0.01344 m³
-> 100 mg/animal corresponds to atmospheric concentration of 100 mg/0.01344 m³ = 7440 mg/m³ = 7.4 mg/L air
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- no toxicity observed up to the maximum dose
- Conclusions:
- The 2 h LC0 of 2-Ethyl ethyl capronate in male rats was 7.4 mg/L.
- Executive summary:
In an acute inhalation toxicity study, groups of 5 male young adult Wistar rats were exposed by inhalation route to 2-Ethyl ethyl capronate in 40% Ethanol for 2 hours to whole body at concentrations of 0 and 1%. Animals then were observed for 14 days.
No animals died at the limit concentration of 1% in 40% Ethanol. No clinical signs apart from temporarily impaired general condition directly after inhalation exposure were observed. Pathologically and histologically no compound specific alterations of the target organs (respiratory tract) could be observed.
The 2 h LC0 was >= 1% test substance in 40% Ethanol, corresponding to 100 mg/animal/2 h.
This value was recalculated to mg/L air using mean animal weights (140 g) and standard respiratory rate (0.048 m³ / h / kg bw) to 7.4 mg/L air (nominal).
“The ranges of the acute toxicity estimates (ATE) for inhalation toxicity [according to Regulation (EC) No 1272/2008] are based on 4-hour testing exposures. Conversion of existing inhalation toxicity data which have been generated using a 1-hour exposure can be carried out by dividing by a factor of […] 4 for dusts and mists.”
Based on this, a factor of 2 was used to extrapolate from 2 h exposure to 4 h exposure, resulting in a 4 h LC0 Males >= 3.7 mg/L.
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