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Diss Factsheets
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EC number: 200-562-9 | CAS number: 63-68-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May - June 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: males 38 days, female 42 days
- Weight at study initiation: 100 - 106 g
- Fasting period before study: 15 - 16 h before application of test material
- Housing: individually
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 24°C +/- 0.5°C
- Humidity (%): 60% +/- 3% - Route of administration:
- oral: gavage
- Vehicle:
- other: carboxy äthylcellulose gel 1%
- Details on oral exposure:
- VOLUME APPLIED: 25 mL/kg b.w.
- Doses:
- 6.35, 7.90 and 10.0 g/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 4 weeks
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occured
- Clinical signs:
- other: no clinical signs observed
- Gross pathology:
- no effects observed
- Interpretation of results:
- GHS criteria not met
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Acute oral toxicity
In a well documented non-GLP study (73-0018-DKT) similar to OECD Guideline 401 the LD50 in Sprague-Dawley rats was reported to be >10000 mg/kg bw.
This result was confirmed in another non-GLP study (73-0022-DKT) with exactly the same LD50 (>10000 mg/kg bw).
The low oral toxicity was further confirmed in a GLP guideline study according to the National Standard of the People's Republic of China (2011-0320-DGT) performed with the read-across substance D,L-methionine. In this study a single oral administration of 5610 mg D,L-methionine/kg b.w. did not reveal any signs of toxicity.
Acute inhalation toxicity
No data on acute inhalation toxicity for L-methionine is available. Significant exposure of humans via inhalation is unlikely taking into account the vapour pressure and the particle size of the substance, while exposure of humans via skin contact is likely.
However, there is an in vivo OECD 403 GLP-guideline study (2003 -0590 -DGT) available for the substance D,L-methionine.Read-across of the D,L-methionine study to L-methionine was used due to structural similarities and the physico-chemical similarities of the enantiomers according to Reach regulation (Annex XI, 1.5). Further, L-methionine is present in a considerable amount in racemic methionine (approximatly 50%).The aim of the available limit test with D,L-methionine was to obtain information on the acute inhalative toxicity following a single 4 hour exposure of rats. No signs of toxicity were observed at 5.25 mg test substance/L air.
Acute dermal toxicity
No data on acute dermal toxicity for L-methionine is available. The substance is of very low acute systemic toxicity (LD50 in acute oral toxicity studies > 10000 mg/kg bw). Due to this very low toxicity and the fact that L-methionine with high water solubility and a log P value well below 0 may be too hydrophilic to cross the lipid rich environment of the stratum corneum it is highly improbable that an acute dermal toxicity study would result in any toxicity. Therefore and for animal welfare reasons no further acute dermal toxicity study is justified and the dermal LD50 is assumed to be > 2000 mg/kg bw.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.