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Diss Factsheets
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EC number: 200-562-9 | CAS number: 63-68-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Case report.
Data source
Reference
- Reference Type:
- publication
- Title:
- Adverse event associated with methionine loading test: a case report.
- Author:
- Cottington EM, LaMantia C, Stabler SP, Allen RH, Tangerman A, Wagner C, Zeisel SH, Mudd SH
- Year:
- 2 002
- Bibliographic source:
- Arterioscler Thromb Vasc Biol. 2002 Jun 1;22(6):1046-50.
Materials and methods
- Study type:
- clinical case study
- Principles of method if other than guideline:
- Case report regarding the death of a 69-year-old African American woman who was recruited and consented to participate in a study of methionine-homocysteine metabolism and its relationship to Alzheimer’s disease.
Test material
- Reference substance name:
- L-methionine
- EC Number:
- 200-562-9
- EC Name:
- L-methionine
- Cas Number:
- 63-68-3
- Molecular formula:
- C5H11NO2S
- IUPAC Name:
- L-methionine
Constituent 1
Method
- Subjects:
- - Number of subjects exposed:
- Sex:female
- Age: 69 yeras
- Race: African American woman - Route of exposure:
- oral
- Reason of exposure:
- intentional
- Details on exposure:
- intended dose: 100 mg/kg bw
Although there was no direct evidence that the dose of methionine received was incorrect, the blood analysis data are consistant with a dose approximately 10 times what was intended.
Results and discussion
Any other information on results incl. tables
After 2 h 40 min after the loading dose, the volunteer began to vomit and continued for several hours, during which prochlorperazine and diphenhydramine were given. At about 8 h after the methionine was given, she was taken to the emergency room, subsequently became apneic and pulseless, and was admitted to an intensive care unit. After various other complications, she died 30 d after the methionine load was administered. Retrospective measurements of plasma methionine showed it to be about 200 times the baseline value at 2 h after the dose, even higher at 4 h, and 10 times the baseline value after 2 d. Although there was no direct evidence that the dose of methionine was incorrect, the blood analysis data are consistent with a dose approximately 10 times what was intended (i.e.,∼70 times the dietary requirement).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.