Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 200-891-8 | CAS number: 75-68-3
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
The requirements of REACH are to provide an assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from the relevant available information.
Studies in rats exposed by inhalation show that 1-chloro-1,1-difluoroethane is rapidly absorbed by the lungs. Analysis of selected tissues from rats and dogs exposed by inhalation for 13 weeks did not reveal the presence of 1-chloro-1,1-difluoroethane and no significant increase in inorganic fluoride in the urine was observed. This is consistent with a low metabolisation of the substance, as indicated by physiologically based pharmacokinetics of uptake by inhalation in rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
