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Diss Factsheets
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EC number: 217-978-1 | CAS number: 2028-63-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- exposure for 1, 5, 15 min, 20 h, 24 h; shorter observaton period
- Principles of method if other than guideline:
- Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test).
- GLP compliance:
- no
Test material
- Reference substance name:
- But-3-yn-2-ol
- EC Number:
- 217-978-1
- EC Name:
- But-3-yn-2-ol
- Cas Number:
- 2028-63-9
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-3-yn-2-ol
- Details on test material:
- purity 56.1%
other component: water
according to order sheet from Dec 2nd 1988
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- No further details were provided
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- The test substance was applied in a 55 % solution in water. 0.2 mL/kg bw were used.
- Duration of treatment / exposure:
- 2 animals were treated on different skin areas for 1, 5 and 15 min;
2 animals were treated for 20 h. - Observation period:
- 8 days
- Number of animals:
- 4
- Details on study design:
- After the 1, 5 and 15 min or 20 h application the test substance was washed off. First it was washed with Lutol 9 (100 %) and afterwards with Lutrol 9 in water (50 %). Animals were fixated by binding of the animal to an exposure board during application.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 3.5 h
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: animal died
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 3.5 h
- Max. score:
- 4
- Remarks on result:
- other: animal died
- Other effects:
- Treatment for 20 h led to the death of the animals during exposure. Animals died 3.5 to 20 h after application.
Pathology revealed an increased fluid accumulation in the thoracic region, starting lungedema and diarrhea.
Any other information on results incl. tables
24h | 48 h | d7 | |||||
exposure | animal #1 | erythema | edema | erythema | edema | erythema | edema |
1 ´ | #1 | - | - | - | - | - | - |
#2 | 2 | - | 1 | - | - | - | |
5´ | #1 | - | - | - | - | - | - |
#2 | 1 | - | 1 | - | - | - | |
15´ | #1 | - | - | - | - | - | - |
#2 | 1 | - | 1 | - | - | - | |
20 h | #1 | exitus over night | |||||
#2 | exitus over night |
OECD / Draize Score (max: 4)
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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