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Diss Factsheets
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EC number: 217-978-1 | CAS number: 2028-63-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- lower animal number/group, only 2 doses tested
- Principles of method if other than guideline:
- according to Hill ("The manufacturing chemist's Ass. Program for the labeling of hazardouos chemicals"; Ass. Food. and Drug Off. 18, 142, 1954).
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- But-3-yn-2-ol
- EC Number:
- 217-978-1
- EC Name:
- But-3-yn-2-ol
- Cas Number:
- 2028-63-9
- Molecular formula:
- C4H6O
- IUPAC Name:
- but-3-yn-2-ol
Constituent 1
- Specific details on test material used for the study:
- The pure substance and a solution of 40% were tested.
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data provided
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: water and unchanged
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back skin, shaved, 50 cm2
- Type of wrap if used: lamination
REMOVAL OF TEST SUBSTANCE
Test substance was removed by removing the wrap.
TEST MATERIAL
- Amount(s) applied: 200 mm3/kg (pure) and 80mm3/kg (40 %)
- Concentration: pure and 40 % in water
- Constant volume or concentration used: yes
VEHICLE
For 40 % test substance was mixed with water. - Duration of exposure:
- 24 hours
- Doses:
- 80 and 200 mm3/kg
69 and 172 mg/kg bw (calculated based on density at 20 °C = 0.8616 g/ml, CRC 2008) - No. of animals per sex per dose:
- 3 animals per dose but no sex distribution provided
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 4 weeks
- Frequency of observations and weighing: every 1 - 3 days
- Necropsy of survivors performed: no
- Other examinations performed: clinical signs, body weight, histopathology - Statistics:
- No statistical analysis was performed.
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 69 - < 172 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original range: > 80 to < 200 mm3/kg bw , mg/kg bw calculated based on density at 20 °C = 0.8616 g/ml
- Mortality:
- All animals treated with the pure test substance (200 mm3/kg bw) died within 8 - 24 hours after application.
All animals treated with the 40 % test substance (80 mm3/kg bw) survived the application. - Clinical signs:
- Animals treated with the pure test substance developed apathy and diarrhea before death.
Animals treated with the 40 % test substance were atonic and apathetic but recovered within 24 h. - Body weight:
- Survivors showed no weight loss.
- Gross pathology:
- Increased fluid accumulation in the thoracic region, liver and kidneys enrichment with blood was detected in animals treated with the pure test substance.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
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