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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- screening for reproductive / developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Data sheet (in fiscal 2010): prepared by Hazard-Data Evaluation Committee of National Institute of Technology and Evaluation based on the GLP study report obtained by Japanese Ministry of Economy, Trade and Industry.
- Title:
- Unnamed
- Year:
- 2 010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Quinolin-8-ol
- EC Number:
- 205-711-1
- EC Name:
- Quinolin-8-ol
- Cas Number:
- 148-24-3
- Molecular formula:
- C9H7NO
- IUPAC Name:
- quinolin-8-ol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- - Molecular weight: 145.16
- Molecular formula: C9H7NO
- Appearance: Solid
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age at study initiation of dosing: 9 weeks old
- Recovery: 0, 400 mg/kg/day
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: methylcellulose solution
- Details on exposure:
- - Male: 42 days
- Female: 42 - 46 days (from 14 days before mating to day 4 of lactation)
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 100 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 200 mg/kg bw/day (actual dose received)
- Dose / conc.:
- 400 mg/kg bw/day (actual dose received)
- Control animals:
- yes, concurrent vehicle
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Male: Salivation (400 mg/kg/day)
Female: Salivation (400 mg/kg/day), Ptosis (400 mg/kg/day), Lacrimation (400 mg/kg/day), Soiled periurogenital fur (400 mg/kg/day) - Mortality:
- no mortality observed
- Body weight and weight changes:
- effects observed, treatment-related
- Description (incidence and severity):
- Male: Decrease in the body weight gain (400 mg/kg/day, tendency), Increase in the body weight gain (Recovery 400 mg/kg/day)
Female: Decrease in the body weight and body weight gain (400 mg/kg/day), Decrease in the body weight (Recovery 400 mg/kg/day, tendency), Increase in the body weight gain (Recovery 400 mg/kg/day, tendency) - Food consumption and compound intake (if feeding study):
- effects observed, treatment-related
- Description (incidence and severity):
- Female: Decrease in the food consumption (400 mg/kg/day)
- Food efficiency:
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Female: Increase in the MCV and Plt (400 mg/kg/day), Decrease in the RBC (400 mg/kg/day, tendency), Increase in the RET (400 mg/kg/day, tendency)
- Clinical biochemistry findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Female: Decrease in the ALP (400 mg/kg/day), Decrease in the ALT (400 mg/kg/day), Increase in Cl (400 mg/kg/day), Decrease in the Alb (400 mg/kg/day), Decrease in the A/G (400 mg/kg/day, tendency), Increase in the T-Cho and Ca (Recovery 400
mg/kg/day), Decrease in Cl and gamma-GTP (Recovery 400 mg/kg/day) - Urinalysis findings:
- effects observed, treatment-related
- Description (incidence and severity):
- Male: Decrease in K (200 and 400 mg/kg/day), Protein positive (400 mg/kg/day)
- Behaviour (functional findings):
- effects observed, treatment-related
- Description (incidence and severity):
- Male: Salivation (200 and 400 mg/kg/day)
Female: Salivation (200 and 400 mg/kg/day), Decrease in the numbers of supported rearing (200 and 400 mg/kg/day), Decrease in the numbers of unsupported rearing (400 mg/kg/day) - Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Description (incidence and severity):
- Female: Decrease in the incidence of vacuolar degeneration of hepatocyte (400 mg/kg/day), Erosion, ulcer, polymorphonuclear cell infiltration and squamous hyperplasia in the forestomach (400 mg/kg/day), Ulcer, polymorphonuclear cell infiltration and
regenerative epithelium in the glandular stomach, cecum and colon (400 mg/kg/day), Increased extramedullary hematopoiesis in the spleen (400 mg/kg/day), Increased pigment deposition in the spleen (Recovery 400 mg/kg/day), Atrophy of the thymus (400 mg/kg/day)
Effect levels (P0)
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 200 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- body weight and weight gain
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 200 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- body weight and weight gain
- food consumption and compound intake
- other: gastrointestinal disorder
Results: F1 generation
Effect levels (F1)
- Key result
- Dose descriptor:
- NOAEL
- Generation:
- F1
- Effect level:
- 400 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: no adverse effects observed at the highest dose tested
Overall reproductive toxicity
- Key result
- Reproductive effects observed:
- no
Applicant's summary and conclusion
- Conclusions:
- No adverse effects on reproduction/development was observed the the OECD422 screening study. Thus, the NOAEL for reproductive/developmental toxicity was concluded to be 400 mg/kg bw/day.
- Executive summary:
Quinolin-8-ol was studied for oral toxicity in rats according to the OECD Test Guideline 422 at doses of 0, 100, 200, and 400 mg/kg. In the repeated dose oral toxicity test, salivation was observed in the 200 and 400 mg/kg groups of both sexes. However, salivation was not considered to be the treatment-related toxic effect, because it was the slight and transitory change. On functional observation battery (FOB) test, lower numbers of supported rearing were observed in female in the 200 and 400 mg/kg groups, but it was not considered to be treatment-related suppression on CNS because there were no effects in other parameters. Body weight gain in males receiving 400 mg/kg tended to be lower than those in the control group. Body weight gain and food consumption in females receiving 400 mg/kg were lower than those in the control group. On urinalysis of males, low potassium excretion was noted in the 200 and400 mg/kg groups, the number of protein-positives was increased in the 400 mg/kg group during the administration period. However, these changes were considered to be a minor toxicological implication, because there were no histopathological lesions about renal function at the end of the administration period. Histopathological evaluation demonstrated some gastrointestinal disorder in females receiving 400 mg/kg. There were no treatment-related findings at the recovery period. Therefore, it was concluded that body weight and food consumption changes, and gastrointestinal disorder were corrected during the recovery period.
In terms of reproductive/developmental toxicity, there were no adverse effects on reproductive ability, including delivery and lactation. Observation of pups revealed no effects of the test substance on viability, body weights, morphology or necropsy findings.
For males, the NOEL for repeated dose oral toxicity test was considered to be100 mg/kg/day, because salivation was observed in the 200 mg/kg group, and the NOAEL was considered to be 200 mg/kg/day, because the tendency of suppression of body weight gain was observed in the 400 mg/kg group. For females (dams), the NOEL for repeated dose oral toxicity test was considered to be 100 mg/kg/day, because salivation and decreased number of supported rearing in the FOB were observed in the 200 mg/kg group, and the NOAEL was considered to be 200 mg/kg/day, because the suppression of body weight gain, lower food consumption and gastrointestinal disorder were observed in the 400 mg/kg group.
The NOEL and NOAEL for pups were considered to be 400 mg/kg/day, because there were no treatment-related changes in all parameters.
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