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EC number: 205-711-1 | CAS number: 148-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1 May 1981
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 12 May 1981
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Quinolin-8-ol
- EC Number:
- 205-711-1
- EC Name:
- Quinolin-8-ol
- Cas Number:
- 148-24-3
- Molecular formula:
- C9H7NO
- IUPAC Name:
- quinolin-8-ol
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- The test substance "HYDROXYQUINOLINE" was supplied by AAGRUNOL – STÄHLER, Pflanzenschutzunion GmbH & Co. KG., D-2160 Stade/Elbe. This product is a whitish-grey, coarse crystalline substance, which was supplied in a paper bag.
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Paderborn
- Weight at study initiation: aaproximately 170 g
- Housing: individual cages
- Diet (e.g. ad libitum): ad libitum standard laboratory diet (supplied by Altromin
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22°C ± 2°C,
- Humidity (%): 50% - 60%
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- For the purpose of the test, the substance was crushed and heavily moistened before being applied to the shaved backs of the rats. The product was easy to apply as a paste. The rats behaved somewhat more calmly than normal following application, which can be attributed to the occlusive dressing.
- Duration of exposure:
- 24h
- Doses:
- 0, 5mg/kg, 10mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- In order to apply the substance optimally and achieve good skin contact, the rats were shaved down to the bare skin along their backs. The entire trunk was wrapped in 2 layers of gauze and the heavily moistened substance was applied to the shaved area. The treated area was covered with a thin plastic film, over which a Stülpa bandage was applied. To prevent slippage, the entire trunk was secured with Leukoplast adhesive plaster; at the same time, this prevented any oral intake or evaporation of the moistened substance. This occlusive dressing was left in place on the rats for 24 hours. Then the rats were carefully "unwrapped" and cleaned with a warm, moist cloth. They were dried with a warm air device and then replaced in their cages. Following the dermal application, the rats were kept in individual cages and observed for 14 days, the criteria for assessment being the symptoms of toxicosis, clinical behaviour and mortality rate. On the 14th day post administration, the rats were killed, dissected and examined macroscopically for anatomical-pathological changes.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 10 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- no indication of skin irritation up to the relevant limit dose level
- Mortality:
- Group Dose/Test substance 24 hours 7 days 14 days
I = control none 0/10 0/10 0/10
II 5 mg/kg 0/10 0/10 0/10
III 10 mg/kg 0/10 0/10 0/10 - Clinical signs:
- other: No treatment related clinical findings were observed
- Gross pathology:
- The final dissection did not reveal any macroscopic anatomical-pathological findings in the abdominal cavity, chest cavity or cranial cavity. Furthermore, the areas of skin to which the substance was applied did not show any signs of intolerance on the underside.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of the test item quinol-8-ol is higher than 10 000 mg/kg body weight after exposure to Wistar rats.
- Executive summary:
In order to apply the quinolin-8 -ol optimally (0, 5 and 10g/mg bw) and achieve good skin contact, the rats were shaved down to the bare skin along their backs. The entire trunk was wrapped in 2 layers of gauze and the heavily moistened substance was applied to the shaved area. The treated area was covered with a thin plastic film, over which a Stülpa bandage was applied. This occlusive dressing was left in place on the rats for 24 hours. Following the dermal application, the rats were kept in individual cages and observed for 14 days, the criteria for assessment being the symptoms of toxicosis, clinical behaviour and mortality rate. On the 14th day post administration, the rats were killed, dissected and examined macroscopically for anatomical-pathological changes. No mortality up to 14 days post administration was observed. The final dissection did not reveal any macroscopic anatomical-pathological findings in the abdominal cavity, chest cavity or cranial cavity. In the activity test during the follow-up observation period, even the rats in the highest dosage group displayed no clear deviation from normal behaviour. Weight development and feed intake were also normal
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