Registration Dossier
Registration Dossier
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EC number: 217-110-1 | CAS number: 1742-95-6
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from Authoritive Data Base
Data source
Reference
- Reference Type:
- other: Authoritive Data Base
- Title:
- Skin sensitization CAS No: 2243-62-1 (1,5-Naphthalenediamine)
- Author:
- IFA (GESTIS)
- Year:
- 2 016
- Bibliographic source:
- GESTIS Substance Database (Information System in Hazardous Substance of the Berufsgenossenscheftn)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin sanitization test of 1, 5 Naphthalenediamine was conducted in humans to determine its sensitization potential.
- GLP compliance:
- not specified
- Type of study:
- not specified
Test material
- Reference substance name:
- 1, 5-Naphthalenediamine
- IUPAC Name:
- 1, 5-Naphthalenediamine
- Reference substance name:
- 1,5-naphthylenediamine
- EC Number:
- 218-817-8
- EC Name:
- 1,5-naphthylenediamine
- Cas Number:
- 2243-62-1
- IUPAC Name:
- naphthalene-1,5-diamine
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): 1, 5-Naphthalenediamine (ND)
- Molecular formula: C10H10N2
- Molecular weight: 158.203g/mol
- Substance type: organic
- Physical state: solid
- Smiles: c12c(c(ccc2)N)cccc1N
-InChI:1S/C10H10N2/c11-9-5-1-3-7-8(9)4-2-6-10(7)12/h1-6H,11-12H2
Constituent 1
Constituent 2
In vivo test system
Test animals
- Species:
- human
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- No data available
Challengeopen allclose all
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- No data available
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Clinical observations:
- Potential contact allergen
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Clinical observations: Potential contact allergen.
Any other information on results incl. tables
The substance is a potential contact allergen
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material 1, 5-Naphthalenediamine (CAS No:- 2243-62-1)observed to be sensitizing to humans.
- Executive summary:
The skin sensitization study of 1, 5-Naphthalenediamine (CAS No:-2243-62-1) was performed in humans to determine its sensitization.
Since the test chemical produced potential contact allergy,1, 5-Naphthalenediamine(CAS No: -2243-62-1) can be concluded as skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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