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EC number: 217-110-1 | CAS number: 1742-95-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The predicted data from QSAR model suggests the lethal concentration (LC50) for the 4-aminonaphthalene-1,8-dicarboximide was estimated to be 321.484771729 mg/L on fish Brachydanio rerio on the basis of mortality effect.
Based on the predicted lethal concentration concluded that the test substance 4-aminonaphthalene-1,8-dicarboximide is non toxic to fish and thus not consider for the aquatic classification as per the CLP criteria.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 321.485 mg/L
Additional information
Predicted model data and experimental study result for the test chemical 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) with respective read across were reviewed to summarize the following information:
In key study the 96 hrs aquatic toxicity study was predicted to assess toxic effects of the test compound 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6)and the result were predicted (SSS QSAR Prediction model, 2016). The study was based on the effects of the test compound on Danio rerio fish in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compound was estimated to be 321.484771729 mg/l on the basis of mortality effect.
Whereas supporting model which is based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10 (EPI Suite, 2016), the 96 hours LC50 was estimated to be 1179.148 mg/l on fish for substance 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) with mortality effects.
Above predicted lethal concentrations for target chemical supported by experimental study for read across chemical Phthalimide (Cas no. 85-41-6) which is indicates that acute toxicity test of Phthalimide to Oryzias latipes according to OECD Guideline 203 (Fish, Acute Toxicity Test) the dose concentration- control, 55.6 mg/L, 100.0 mg/L (nominal concentrations) was used at 24±1 degreeC test temp.,6.6 - 7.1 pH and 5.1 - 11.0 mg/l (Saturated concentration at 24 °C is 8.25 mg/l) dissolved oxygen in semi static freshwater condition for 96 hrs.
During experiment the lethal concentration (LC50) was found to be 100 mg/l with 95% confidence limit of 55.6 ->100 mg/l.(Japan chemicals collborative knowledge database (J-check); 2016)
Thus, based on above all lethal concentration values, it can be concluded that the target chemical 4-aminonaphthalene-1,8-dicarboximide (CAS No. 1742-95-6) can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
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