Registration Dossier
Registration Dossier
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EC number: 604-939-2 | CAS number: 154095-77-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- results derived from a (Q)SAR model, with limited documentation / justification
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- Unnamed
- Year:
- 2 015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July2008
- GLP compliance:
- not specified
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- (17β)-13-ethyl-3-methoxy-gona-1,3,5(10)-trien-17-yl acetate
- EC Number:
- 604-939-2
- Cas Number:
- 154095-77-9
- Molecular formula:
- C22H30O3
- IUPAC Name:
- (17β)-13-ethyl-3-methoxy-gona-1,3,5(10)-trien-17-yl acetate
- Test material form:
- solid: crystalline
- Details on test material:
- Test item: trienol acetateCas No.: 154095-77-9Batch No.: J65084NStorage: 15-30 °C
Constituent 1
Results and discussion
In vivo (LLNA)
Results
- Parameter:
- EC3
- Value:
- 21.4
- Remarks on result:
- positive indication of skin sensitisation based on QSAR/QSPR prediction
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (indication of skin sensitising potential) based on GHS criteria
- Conclusions:
- According to (Q)SAR modell: QSAR Toolbox, the predicted value indicated that trienol-acetate is sensitiser. The result meets the requirement of Hazard Category 1B.
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