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EC number: 204-320-3 | CAS number: 119-40-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modeling database
- Principles of method if other than guideline:
- ECOSAR v1.00
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- other: Fish
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 2 917.242 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 2917.242 mg/l on fish for substance 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid with mortality effects. Thus based on this value it can be concluded that the substance can not be consider for the aquatic classification as per the criteria of CLP regulation.
- Executive summary:
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 2917.242 mg/l on fish for substance 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid with mortality effects. Thus based on this value it can be concluded that the substance can not be consider for the aquatic classification as per the criteria of CLP regulation.
Reference
Description of key information
Based on the QSAR prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 2917.242 mg/l on fish for substance 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid with mortality effects. Thus based on this value it can be concluded that the substance can not be consider for the aquatic classification as per the criteria of CLP regulation.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 2 917.242 mg/L
Additional information
Predicted model data and experimental study result for the test chemical 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid (CAS No. 119-40-4) with respective read across were reviewed to summarize the following information:
In key study the QSAR prediction done using the EPI Suite ECOSAR version 1.10 (EPI Suite, 2016), the 96 hours LC50 was estimated to be 2917.242 mg/l on fish for substance 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid (CAS no. 119-40-4) with mortality effects.
Above predicted data supported by experimental study from GSBL – Joint Substance Data Pool of the German Federal Government and the German Federal States; 2015 which indicate based on effects such as O2 consumption, growth, mortality and buoyancy, the 96 hrs LC0 value for test substance 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid was found to be 100 mg/l.
From peer reviewed journal Chemophere. Vol. 28, No. 12, pp. 2203.2236, 1994 following studies available for different read across substances:
For read across chemical 7-Amino-4 hydroxy- 2 – naphthalenesulphonic acid (Cas no. 87-02-5) which is indicates lethal concentration (LC0) of test substance 7-amino-4-hydroxy-2-naphthalene-sulfonic acid for fish Leuciscus idus, Bruchydunio rerio,Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate was found to be 1000 mg/l for 96 hrs.
For read across chemical 7-hydroxy-1,3-naphthalene –disulfonic acid,dipotassium salt (Cas no. 842-18-2) which is indicates lethal concentration (LC0) of test substance 7-hydroxy-1,3-naphthalene –disulfonic acid,dipotassium salt for fish Leuciscus idus, Bruchydunio rerio,Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate was found to be >=1000 mg/l for 72 hrs.
For read across chemical 6-amino-4-hydroxy-2-naphthalene-sulfonic acid (Cas no. 90-51-7) which is indicates lethal concentration (LC0) of test substance 6-amino-4-hydroxy-2-naphthalene-sulfonic acid for fish Leuciscus idus, Bruchydunio rerio,Salmo gaidneri, Pimephales promelas, Lepomis macrochirus, Poecilia reticulate was found to be 1000 mg/l for 48 hrs.
Thus, based on above all lethal concentration values, it can be concluded that the target chemical 7-Anilino-4-hydroxynaphthalene-2-sulphonic acid (CAS No. 119-40-4) can be considered as non-toxic to fish and thus cannot be classified as hazardous as per the CLP criteria.
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