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EC number: 233-546-5 | CAS number: 10226-30-9
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
96 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound 6-Chlorohexan-2-one (CAS no 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on the fish Poecilia reticulata in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compound 6-Chlorohexan-2-one was estimated to be 326.88168335 mg/L on the basis of mortality.
Based on the result the chemical was considered as not classified as per CLP regulations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 326.882 mg/L
Additional information
Various predicted data for the target chemical 6-Chlorohexan-2-one (CAS No. 10226-30-9) were reviewed for short term toxicity to fish endpoint to summarize the following information:
96 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound 6-Chlorohexan-2-one (CAS no 10226-30-9) and the results were predicted. The study was based on the effects of the test compound on the fish Poecilia reticulata in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compound 6-Chlorohexan-2-one was estimated to be 326.88168335 mg/L on the basis of mortality.
Other prediction done using the EPI Suite ECOSAR version 1.10, the 96 hours LC50 was estimated to be 315.61 mg/L for fish for substance 6-chlorohexan-2-one with mortality effects.
Whereas, QSAR predictions is done using the Danish (Q)SAR Database and ECOSAR indicate that the 96 hrs LC50 value by three different model i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database was found to be 60.86555 mg/l. Since the test substance is readily biodegradable in nature and the partition coefficient (log Kow) of the test chemical is not ≥ 4 (i.e, reported as 1.49) therefore test chemical can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.
Thus based on the above all predicted model results it is concluded that the test substance 6-Chlorohexan-2-one (CAS No. 10226-30-9) is non toxic to fish and thus not consider for the further classification.
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