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EC number: 235-440-4 | CAS number: 12227-78-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Link to relevant study records
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from QSAR Toolbox version 3.3
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.3
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
- Target gene:
- Salmonella typhimurium
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not applicable
- Metabolic activation:
- with and without
- Metabolic activation system:
- Rat liver S9-mix induced by a combination of phenobarbital and β-naphthoflavone
- Test concentrations with justification for top dose:
- No data
- Vehicle / solvent:
- Milli-Q water
- Untreated negative controls:
- no
- Negative solvent / vehicle controls:
- yes
- True negative controls:
- no
- Positive controls:
- yes
- Details on test system and experimental conditions:
- METHOD OF APPLICATION: in agar (plate incorporation)
DURATION
- Exposure duration: 48 ± 4 h at 37.0 ± 1.0 °C
NUMBER OF REPLICATIONS: 3 plates/dose for Experiment 1 and 2 - Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
- Conclusions:
- Interpretation of results (migrated information):
negative
The substance 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium salt is estimated to be non mutagenic in an in vitro bacterial reverse mutation assay - Executive summary:
Genetoxicity of 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium saltis predicted using QSAR toolbox version 3.3.
The substance 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium salt is estimated to be non mutagenic in an in vitro bacterial reverse mutation assay
Reference
The prediction was based on dataset comprised from the following descriptors: "gene mutation"
Estimation method: Takes highest mode value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
(((("a" or "b" or "c" or "d" or "e" ) and "f" ) and ("g" and ( not "h") ) ) and ("i" and "j" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Aluminum Compounds OR Phenols (Chronic toxicity) by US-EPA New Chemical Categories
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Aryl AND Aryl halide AND Carboxylic acid AND Fused carbocyclic aromatic AND Fused saturated heterocycles AND No functional group found AND Phenol AND Xanthene by Organic Functional groups
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Aryl AND Aryl halide AND Carboxylic acid AND No functional group found AND Overlapping groups AND Phenol AND Xanthene by Organic Functional groups (nested)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Acid, aromatic attach [-COOH] AND Alcohol, olefinic attach [-OH] AND Aliphatic Carbon [CH] AND Aliphatic Carbon, two phenyl attach [-C-] AND Aliphatic Oxygen, two aromatic attach [-O-] AND Aluminium [Al] AND Aromatic Carbon [C] AND Carbonyl, olefinic attach [-C(=O)-] AND Carbonyl, one aromatic attach [-C(=O)-] AND Hydroxy, aromatic attach [-OH] AND Iodide, aromatic attach [-I] AND Miscellaneous sulfide (=S) or oxide (=O) AND Olefinic carbon [=CH- or =C<] AND Oxygen, one aromatic attach [-O-] AND Oxygen, two olefinic attach [-O-] AND Tertiary Carbon by Organic functional groups (US EPA)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Aromatic compound AND Aryl halide AND Aryl iodide AND Carbonic acid derivative AND Carboxylic acid AND Carboxylic acid derivative AND Diarylether AND Ether AND Halogen derivative AND Heterocyclic compound AND Hydroxy compound AND No functional group found AND Phenol by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as High (Class III) by Toxic hazard classification by Cramer (with extensions) ONLY
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Halogens AND Metals AND Non-Metals by Groups of elements
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Alkali Earth OR Alkaline Earth OR Metalloids by Groups of elements
Domain logical expression index: "i"
Parametric boundary:The target chemical should have a value of log Kow which is >= 2.57
Domain logical expression index: "j"
Parametric boundary:The target chemical should have a value of log Kow which is <= 7.77
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Genetic toxicity in vitro
Genetoxicity of 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium saltis predicted using QSAR toolbox version 3.3.
The substance 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium salt is estimated to be non mutagenic in an in vitro bacterial reverse mutation assay
Various studies conducted on similar substance (CAS: 16423-68-0) are also reported:
In multiple studies by T.P. Cameron et. al, (1987) the test material C. I -ACID RED 51 was determined to be negative for gene mutation in Salmonella typhimurium TA1535, TA1537, TA1538, TA100 and TA98 with and without metabolic activation by Plate-incorporation method.
The test material C. I ACID RED 51 failed to induce gene mutation in Salmonella typhimurium strains TA98 and TA100 in the FMN-modified assay.
In another study by the same author, The C. I ACID RED 51 (16423-68-0) was found to be positive (with and without S9 mix) in L5178Y TK +/- mouse lymphoma cell line.
In another study (C.G. Rogers et. al, 1988) , Erythrosine (FD and C Red No. 3) failed to induce gene toxicity in vitro and cytotoxicity in the V79 hepatocyte-mediated mutation assay performed on V79 Chinese hamster lung cells.
Another study (Yasuhide Tonogai et. al 1979), indicates that Erythrosine failed to induce gene mutation in Bacillus subtilis H17 (Rec+) and M45 (Rec-) in the rec assay.
Overall reported genetic toxicity studies of target and read-across substance, indicate that 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium salt is not likely to exhibit genetic toxicity can be classified as 'non-hazardous' as per the CLP classification criteria
Justification for selection of genetic toxicity endpoint
Genetoxicity of 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium saltis predicted using QSAR toolbox version 3.3.
The substance 2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium salt is estimated to be non mutagenic in an in vitro bacterial reverse mutation assay
Justification for classification or non-classification
Based on the information available for the target as well as read-across substance,2-(3,6-dihydroxy-2,4,5,7-tetraiodoxanthen-9-yl)benzoic acid, aluminium salt is not likely to result in genetiic toxicity and is hence classified as non hazardous as per the CLP criteria.
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