Registration Dossier
Registration Dossier
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EC number: 203-572-1 | CAS number: 108-32-7
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only summary data provided with limited information on methods and results.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Final report on the safety assessment of propylene carbonate
- Author:
- Beyer KH Jr., Bergfeld WF, Berndt, WO, et al.
- Year:
- 1 987
- Bibliographic source:
- Journal of the American College of Toxicology Vol 6, (1)
Materials and methods
- Principles of method if other than guideline:
- Acute exposure to concentrated vapours over 8 hours followed by a 14 day observation period.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propylene carbonate
- EC Number:
- 203-572-1
- EC Name:
- Propylene carbonate
- Cas Number:
- 108-32-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- 4-methyl-1,3-dioxolan-2-one
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Details on inhalation exposure:
- Exposure to concentrated vapours for 8 hours
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 8 h
- Concentrations:
- No data
- No. of animals per sex per dose:
- 6 animals
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
- Mortality:
- Not lethal
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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