Methyl decanoate

Ecotoxicological Summary

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:

PNEC aqua (freshwater)

PNEC value:

0.001 mg/L

Assessment factor:

50

Extrapolation method:

assessment factor

PNEC freshwater (intermittent releases):

0.011 mg/L

Marine water

Hazard assessment conclusion:

PNEC aqua (marine water)

PNEC value:

0 mg/L

Assessment factor:

500

Extrapolation method:

assessment factor

STP

Hazard assessment conclusion:

PNEC STP

PNEC value:

100 mg/L

Assessment factor:

10

Extrapolation method:

assessment factor

Sediment (freshwater)

Hazard assessment conclusion:

PNEC sediment (freshwater)

PNEC value:

0.047 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:

PNEC sediment (marine water)

PNEC value:

0.005 mg/kg sediment dw

Extrapolation method:

equilibrium partitioning method

Hazard for air

Air

Hazard assessment conclusion:

no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:

PNEC soil

PNEC value:

10 mg/kg soil dw

Assessment factor:

100

Extrapolation method:

assessment factor

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:

PNEC oral

PNEC value:

66.6 mg/kg food

Assessment factor:

300

Conclusion on classification

According to Article 13 of Regulation (EC) No. 1907/2006 "General Requirements for Generation of Information on Intrinsic Properties of substances", information on intrinsic properties of substances may be generated by means other than tests e.g. from information from structurally related substances (grouping or read-across), provided that conditions set out in Annex XI are met.

Annex XI, "General rules for adaptation of this standard testing regime set out in Annexes VII to X” states that “substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or ‘category’ of substances…This avoids the need to test every substance for every endpoint”.

Since the group concept is applied to the members of the SCAE Me category, data will be generated from a representative category member to avoid unnecessary animal testing. Additionally, once the group concept is applied, substances will be classified and labelled on this basis.

Classification related key information

Biodegradation in water: screening tests:

78% biodegradation in 28 days (read-across) (OECD 301C)    

                                                                    

Bioaccumulation:                       

No significant bioaccumulation in biota is expected for this substance (see IUCLID section 5.3).

 

Acute toxicity:

-         Fish: LC50 (48 h) = 1700 mg/L for Leuciscus idus (DIN 38412/15)

LC50 (48 h) > 100 < 300 for Leuciscus idus (read across) (DIN 38412/15)

LC50 (48 h) = 170 mg/L for Leuciscus idus (read-across) (DIN 38412/15)

LC50 (96 h) > 0.52 mg/L (measured) for Oryzias latipes (read-across) (OECD 203)

-         Aquatic invertebrates: EC50 (48 h)= 1.1 mg/L for Daphnia magna (OECD 202)

-         Algae: EC50 (72 h) > 0.055 mg/L for Pseudokirchneriella subcapitata (OECD 201)

                  EC50 (96 h) = 1.35 mg/L for green algae (QSAR)

 

Chronic toxicity:

-         Aquatic invertebrates: NOEC (21 d) = 0.0814 mg/L for Daphnia magna (read-across) (OECD 211)

-         Algae: NOEC (72 h) = 0.055 mg/L for Pseudokirchneriella subcapitata (OECD 201)

 

Classification justification according to CLP

Based on the data above, the acute aquatic toxicity L(E)C50 values are > 1 mg/L for Leuciscus idus, Daphnia magna and Pseudokirchneriella subcapitata. Methyl decanoate does not need to be classified and labeled as acute aquatic hazard according to the 2nd ATP of Regulation (EC) No. 1272/2008 (CLP).

 

Methyl decanoate is considered to be rapidly degradable. Valid chronic toxicity data are available on Daphnia magna and Pseudokirchneriella subcapitata, for which NOEC values < 1 mg/L were reported (lowest NOEC (72 h)= 0.055 mg/L for Pseudokirchneriella subcapitata).Thus,methyl decanoate needs to be classified and labelled as long-term aquatic hazard Chronic Category 2 according tothe 2nd ATP of Regulation (EC) No. 1272/2008 (CLP).

 

M-factor for chronic aquatic toxicity: not to be assigned.

 

Classification justification according to DSD

Based on the data above, methyl decanoate (CAS No. 110-42-9) is considered to be rapidly biodegradable and have low bioaccumulation potential. The acute aquatic toxicity tests available resulted in EC50 values > 1 mg/L for Leuciscus idus, Daphnia magna and Pseudokirchneriella subcapitata.Thus, methyl decanoate does not need to be classified and labelled according to Directive 67/548/EEC.