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EC number: 267-008-6 | CAS number: 67762-27-0 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol and SDA Reporting Number: 19-060-00.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to birds
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Alcohols, C16-18 is a member and is from Long Chain Alcohols (C6-22 primary aliphatic alcohols) category.
The Long Chain Alcohols (C6-22 primary aliphatic alcohols) category is considered suitable as a source of data for Alcohols, C16-18.
Considered valid for read-across for purposes of classification.
No further vertebrate testing can be justified.
Long Chain Alcohols (C6-22 primary aliphatic alcohols) category covers a family of 30 primary aliphatic alcohols within a carbon chain length range of C6-C22. Commercial products generally include several aliphatic alcohol components, with a range of carbon chain lengths present. The family consists of alcohols with varying compositions and structures. Composition depends on the route to manufacture and the related feedstocks. Most of the alcohols have linear carbon chains but certain manufacturing processes create branched structures. Data are also available for eleven other similar substances, which support the category. Non-sponsored alcohols may not be HPV or may not be produced by members of the consortium, but have structures similar to sponsored linear alcohols.
Key points are that the members share:
• The same structural features
• Similar metabolic pathways
• Common mode of ecotoxicological action
• Common levels and mode of human health related effects. - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 223 (Avian Acute Oral Toxicity Test)
- GLP compliance:
- not specified
- Dose method:
- feed
- Analytical monitoring:
- not specified
- Vehicle:
- no
- Test organisms (species):
- other: Gallus domesticus
- Details on test organisms:
- TEST ORGANISM
- Common name: Domestic Chicken
- Disease free: yes /
- Kept according to standard practices: yes /
Gallus domesticus (Domestic Chicken). The organism(s) (age: 1 d and organism characteristics of: 39.7 G,WHITE LEGHORN AND BROILER) were exposed for a duration of 3 week(s) to a(n) NR ad libitum; without limit or restraint application of 1-Octanol (CAS # 111875) in NR carrier or a(n) NR positive control through a(n) chemical incorporated into the food exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. - Limit test:
- no
- Total exposure duration (if not single dose):
- 3 wk
- No. of animals per sex per dose and/or stage:
- Gallus domesticus (Domestic Chicken). The organism(s) (age: 1 d and organism characteristics of: 39.7 G,WHITE LEGHORN AND BROILER)
- Control animals:
- not specified
- Nominal and measured doses / concentrations:
- 10 % of diet of 1-Octanol corresponds to 100 000 ppm (mg/l).1 ppm in the diet of chick is equavalent to 0.125 mg/kg bw per day. Consequently 100000 ppm is equavalent to 12500 mg/kg bw per day (100000x 0.125).
- Details on test conditions:
- TEST CONDITIONS
STUDY TYPE:
MEDIA TYPE- NONE (no substrate)
EXPOSURE TYPE- FD (Food)
LOCATION: LAB (Laboratory, indoor)
CONTROL: C (concurrent control),
The total number of exposure doses - 3 week(s) to a(n) NR ad libitum; without limit or restraint application of 1-Octanol (CAS # 111875)
EXPOSURE DUR.: 3 week(s)
STAND DUR. (D): 3 week(s)
TEST CONCENTRATION
CHEM ANAL. METHOD: unmeasured
UNIT OF MEASURE: mg/l
TYPE VALUE RANGES STANDARD CONC (mg/L) IONCIC FRACTION
T 100000 NR to NR 100000 mg/L - Details on examinations and observations:
- MORTALITY / CLINICAL SIGNS
- Time schedule for examinations: :3 weeks
- Remarks:
BODY WEIGHT
- Time schedule for examinations:: 3 weeks
- Remarks:
FOOD CONSUMPTION (if feeding study)
- Time schedule for examinations:3 weeks
- Remarks: Gallus domesticus (Domestic Chicken). The organism(s) (age: 1 d and organism characteristics of: 39.7 G,WHITE LEGHORN AND BROILER) were exposed for a duration of 3 week(s) to a(n) NR ad libitum; without limit or restraint application of 1-Octanol (CAS # 111875) in NR carrier or a(n) NR positive control through a(n) chemical incorporated into the food exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. - Details on reproductive parameters:
- Under the conditions of the test of Yoshida, M., and H. Hoshii1971, 1-Octanol induced No Mortality in Gallus domesticus below 1250 mg/kg bw (NOAEL).
- Reference substance (positive control):
- not specified
- Duration (if not single dose):
- 3 wk
- Dose descriptor:
- NOEL
- Effect level:
- 1 250 mg/kg bw/day
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 10 % of diet of 1-Octanol corresponds to 100 000 ppm (mg/l).1 ppm in the diet of chick is equavalent to 0.125 mg/kg bw per day.Consequently 100000 ppm is equavalent to 12500 mg/kg bw per day (100000x 0.125). NR-LETH =12500 mg/kg bw, NOEL=1250 mg/kgbw
- Duration (if not single dose):
- 3 wk
- Dose descriptor:
- NOEC
- Effect level:
- 10 000 mg/kg diet
- Conc. / dose based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: Conversion factors from NOEL to NOEC for bird species Gallus domesticus is (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day) NOECbird=1250 x 8=10 000 mg/kg/diet
- Validity criteria fulfilled:
- yes
- Conclusions:
- 10 % of diet of 1-Octanol corresponds to 100 000 ppm (mg/l).1 ppm in the diet of chick is equavalent to 0.125 mg/kg bw per day.Consequently 100000 ppm is equavalent to 12500 mg/kg bw per day (100000x 0.125). NR-LETH =12500 mg/kg bw, NOEL=1250 mg/kg bw
- Executive summary:
A study of NC-NC Not Coded duration using no substrate media was conducted in a Lab site location with Not Coded obtained Gallus domesticus (Domestic Chicken). The organism(s) (age: 1 d and organism characteristics of: 39.7 G,WHITE LEGHORN AND BROILER) were exposed for a duration of 3 week(s) to a(n) NR ad libitum; without limit or restraint application of 1-Octanol (CAS # 111875) in NR carrier or a(n) NR positive control through a(n) chemical incorporated into the food exposure route. The reported chemical concentrations are the result of unmeasured analysis of chemical solutions and are based on the NR ion. (Reference 79054, Yoshida, M., and H. Hoshii, 1971, Test Number 402961).
- Endpoint:
- long-term toxicity to birds
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Referenceopen allclose all
Under the conditions of the present test 1-Octanol induced No Mortality in Gallus domesticus below 1250 mg/kg bw (NOAEL).
Description of key information
Under the conditions of the test of Yoshida, M., and H. Hoshii1971, 1-Octanol induced No Mortality in Gallus domesticus below 1250 mg/kg bw (NOEL).
The NOELs can be converted to NOECs with the following two formulae:
NOECbird=NOAELbird.CONVbird
Conversion factors from NOAEL to NOEC for bird species Gallus domesticus is (bw/dfi)
bw = body weight (g); dfi: daily food intake (g/day)
NOECbird=1250 x 8=10000 mg/kg/diet
LC50=5 x 10000 =50000 mg/kg food
This information will be take into account for birds toxicity for the derivation of PNEC.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for birds:
- 50 000 mg/kg food
- Long-term EC10, LC10 or NOEC for birds:
- 10 000 mg/kg food
Additional information
Under the conditions of the test of Yoshida, M., and H. Hoshii1971, 1-Octanol induced No Mortality in Gallus domesticus below 1250 mg/kg bw (NOEL).
The NOELs can be converted to NOECs with the following two formulae: NOECbird=NOAELbird.CONVbird
Conversion factors from NOAEL to NOEC for bird species Gallus domesticus is (bw/dfi) bw = body weight (g); dfi: daily food intake (g/day)
NOECbird=1250 x 8=10000 mg/kg/diet
LC50=5 x 10000 =50000 mg/kg food
This information will be take into account for birds toxicity for the derivation of PNEC.
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